Regulation of Gene Expression
The Attisano Laboratory investigates how cells receive, passage, and then transmit extracellular signals. Current interests are TGFB, Wnt, and Hippo signalling pathways, whose disruption is associated with numerous diseases including cancer. We also study the formation of axons and dendrites in primary neurons. We use biochemical and cell biological methods to examine mammalian cell, organoids, and mouse model systems.
The Harrington Lab investigates how cells maintain genome integrity through maintenance of chromosome ends, called telomeres. We study how factors influencing the telomeric region impact stem cells, normal cells, and tissues during aging, cancer, and other immunological disorders. We explore biochemical, genetic and epigenetic alterations in normal and cancerous cells across species including yeast, humans, mice, and even wild sheep.
Kapus Lab
The Kapus lab investigates cellular plasticity, particularly as it pertains to epithelial-mesenchymal transition and myofibroblast formation. These processes are critical to tissue repair and are central to the pathobiology of organ fibrosis. We study how the cytoskeleton is remodeled upon exposure to stress and conversely how cytoskeleton remodeling impacts major cell processes including gene expression, ion transport, and organelle functioning.
Muise Lab
The Muise lab focuses on understanding the genetic susceptibility and function of identified genes in pathogenesis of Very Early Onset Inflammatory Bowel disease.
Ohh Lab
Our research mission is to elucidate the molecular mechanisms governing the function of two major cancer-associated proteins called von Hippel-Lindau (VHL) tumour suppressor protein and RAS oncoprotein with the supposition that lessons learned would provide fundamental understanding of cell biology and lay the basic foundation for the development of rational anti-cancer therapeutics.
In the Palazzo lab we are studying the rules that govern whether an RNA molecule is exported from the nucleus and subsequently transported to specific subcellular regions, or whether it is retained in the nucleus and degraded. We use a combination of cell biological, biochemical and computational methods in order to gain insight into these fundamental processes.
Privé Lab
Our research centers on the study of protein structure and molecular recognition, with an emphasis on understanding protein-protein, protein-peptide and protein-lipid interactions.
Dr. Gil Privé
Our lab studies the functional role of genome organization in cell fate decisions – at the single-molecule level & across biological scales. Our work bridges cell & developmental biology, computational biology, biochemistry & systems biology. We push the boundaries of high-throughput image-based spatial omics & bioimage analysis to answer fundamental questions and gain insights into in vivo chromatin biology.
Schulze Lab
The Schulze Lab applies biochemistry, genomics, cell biology, and model systems to improve the understanding of and develop treatments for rare inborn errors of metabolism. The main focus is on Creatine Deficiency Syndromes and Guanidinocompound-/Arginine metabolism and Sanfilippo Syndrome.
Schuurmans Lab
The Schuurmans Lab is focused on the specification of neural cell fates and the control of tissue morphogenesis in the developing central nervous system, in particular in the retina and neocortex. Knowledge of neural development is applied to understand injury response and to create lineage conversion strategies for cell replacement therapies.
Our research group aims to decode the genomic and cellular mechanisms of sleep using comparative approaches across vertebrate species. Our approaches are interdisciplinary and intersect the research areas of functional genomics, bioinformatics, cell & molecular biology, neurobiology, and evolution. We are interested in all species, with particular emphasis on diverse groups of fish, including cichlids from the African Rift Lakes.
Smibert Lab
We are interested in understanding the molecular mechanisms that regulate post-transcriptional gene expression in the cytoplasm. RNA-binding proteins and regulatory mRNAs act to control translation, stability, and subcellular localization of mRNAs. We use the early Drosophila (fruit fly) embryo as a model system and a combination of biochemical, genetic, cell biologic, genome-wide and computational methods in our work.