Frank Sicheri
PhD
Structural Biology of Eukaryotic Signal Transduction
Our research is directed at furthering the understanding of protein kinase regulation with a particular focus towards the underlying structural mechanism that imparts specificity to signalling function. We seek to uncover the structural basis for novel catalytic switching, substrate recognition and down-stream phosphoregulatory mechanisms. In addition, we are interested in uncovering the structure and function of new proteins and activities that impact protein kinase function. These efforts have recently led our lab into the area of ubiquitin directed proteolysis. Our long-term goal is to make use of what we learn about protein kinases and phosphoregulatory systems to develop drugs to treat human disease.
Appointments, Cross Affiliations, Memberships
Professor, Department of Molecular Genetics, University of Toronto
Fellow, Royal Society of Canada
Courses Taught
BCH 2110H Eukaryotic Signaling
BCH374Y1 Research Project in Biochemistry
BCH473Y Advanced Research Project in Biochemistry
Awards and Distinctions
2011 — Fellow, Royal Society of Canada
2009-present — Structural Biology of Signal Transduction, Canada Research Chair (CIHR- Tier 1)
2008 — Merck Frosst Prize, Canadian Society of Biochemistry and Molecular & Cellular Biology
2003 — Terry Fox Young Investigator Scholar National Cancer Institute of Canada / Terry Fox Foundation
1999-2004 — National Cancer Institute of Canada / Canadian Cancer Society Research Scientist Scholar
1998 — Premier’s Research Excellence Award, Ontario Research and Development Challenge Fund
1998 — Canada Foundation for Innovation Researcher
1996-1998 — Human Frontier Science Program, Postdoctoral Fellowship Award