Studies of Tissue Barriers: Regulation of the Phenotype and Transport Across the Epithelium and Endothelium - BCH2120H

Maintenance and regulation of barrier function – which protects the body from a potentially hostile external environment – and separates the vascular system from the tissues it supplies – is a recurring theme in medicine. Defects in barrier function lie at the heart of numerous diseases, including acute respiratory distress syndrome, atherosclerosis and chronic kidney disease.

This course will discuss the mechanisms of barrier function, which is constituted by specialized cells known as the endothelium in blood vessels and, at the interface with the external environment, are made up of the epithelium. Their proper regulation is critical for tissue integrity and normal

Method of Student Evaluation
1) Attendance and participation 20%
2) Grant proposal 40%
3) Journal article presentation 40%

Course Coordinators
Warren Lee, Andras Kapus

Enrollment Limit
10