Structure and Dynamics of Biomacromolecules Using Solid State NMR Spectroscopy - BCH2125H

Solid state NMR spectroscopy is a powerful tool for addressing many questions at the cutting edge of structural biology, allowing elucidation of structure and dynamics for macromolecular assemblies that are often inaccessible to other structural tools. These include, but are not limited to, membrane proteins in lipid membranes, amyloid fibrils, extracellular matrix proteins, and viral capsids.

This course will provide a primer for the practical aspects of acquisition and analysis of solid state NMR data of biological systems, through a combination of in-class lectures and hands-on experiments. The fundamental theory underlying the technique will also be discussed.

Grades will be based on participation, completion of a take-home assignment (processing and interpretation of NMR data acquired in class), and presentation of a journal article (list to be provided).

Method of Student Evaluation:
Attendance/participation – 20%
Presentation – 40%
NMR data analysis - 40%

Course Coordinator:
Simon Sharpe

Enrollment Limit
10