Williams lab unravels the mechanistic basis of a treatment for prion diseases
Prion disease occurs when the normal cellular prion protein (PrPC) is misfolded by a pathogenic form of the protein termed PrP scrapie (PrPSc). One approach to treat prion diseases is to reduce or eliminate PrPC since mice lacking this protein show few ill effects. The human-approved immunosuppressive drug FK506 has been shown to extend survival in prion infected mice but the mechanism has been controversial. In a paper published in the […]
