Seeing the first steps of DNA repair
The laboratories of John Rubinstein and Frank Sicheri (Biochemistry), and Dan Durocher (Molecular Genetics) have used electron cryomicroscopy (cryo-EM) to determine the structure of the DNA-damage recognizing protein 53BP1 bound to modified nucleosome core particles. The work, published in Nature (http://www.nature.com/nature/journal/vaop/ncurrent/full/nature18951.html), was led by postdoctoral fellow Marcus Wilson and research associate Samir Benlekbir and provides the first structural insight into how dimethylation and ubiquitination of nucleosomes in […]
