Congratulations to Professor Alexio Muise who was awarded the Crohn’s and Colitis Canada 2020 Research Leadership Award. Professor Muise’s lab has been performing groundbreaking work into the genetic causes of Inflammatory Bowel Syndrome and has published several ground breaking studies in the past few years.
A new paper in the latest issue of Science describes how the bacterial-sensing proteins, NOD1/2, are recruited to the membranes of our gut cells for them to function to initiate a proper immune response. This involves the addition of a lipid, palmitoyl, to NOD1/2 by the palmitoyl-transferase ZDHHC5. Importantly variants of NOD2 that are associated with Crohn’s disease are unable to be palmitoylated. This work involved an international collaboration […]
Two of Biochemistry’s professors, Drs. Aleixo Muise and Walter Kahr have discovered a brand new genetic disease through their research at the Hospital for Sick Children.
Their research article is published on Nature Communications.
Their story was also highlighted on the Hospital for Sick Children, CBC The National and CBC News Network, and the Globe and Mail websites:
http://www.cbc.ca/news/thenational/new-disease-discovered-1.4054061
In a study published in Cellular and Molecular Gastroenterology and Hepatology, Aleixo Muise, Clinician-Scientist and Co-Director of the IBD Centre, and a team of Sick Kids researchers reveal that a genetic defect causes a mutation of the PLVAP gene. The mutation leads to the loss of the protein filter in blood vessels in the bowel. Further research into this new disease may lead to new treatments and a […]