McQuibban

Angus McQuibban awarded major funding for anti-neurodegenerative diseases drug discovery by AI

24 October 2019|

Professor G. Angus McQuibban has just been awarded a $2.3-million Genome Canada grant.

The GAPP grant in a partnership with Cyclica and Rosetta Therapeutics (founded by Professors Angus McQuibban and Peter Lewis) will support drug discovery related to treating people with the long-term neurodegenerative diseases and will involve the use of artificial intelligence and machine learning. (full story here)

How to protect Peroxisomes and Mitochondria from Dying

6 February 2019|

The regulation of organelle abundance is critical for cell function and survival; however, the mechanisms responsible are not fully understood. Imbalances in organelle abundance can result in disease states, including Parkinson’s Disease resulting from dysregulated mitochondrial homeostasis. Peroxisome dysregulation also results in disease, most notably the Zellweger’s spectrum disorders. Although first considered to be caused exclusively by reduced peroxisome biogenesis, recently work shows that the most are due to increase […]

Yuqing Wang

Grad Student Yuqing Wang featured in Faculty of Medicine News article

5 March 2015|

 

Yuqing Wang was featured in the article She Does It Her Way (And It Works) for the Faculty of Medicine News webpage. Yuqing, a PhD grad student in the Peter Kim and Angus McQuibban Labs, discussed her challenges and numerous triumphs in her studies and life in Canada.

 

 

ommatidial array

McQuibban and McNeill labs reveal a novel signaling pathway, published in Cell

17 September 2014|

Planar cell polarity (PCP), is a form of tissue organization that is critical for normal development. Dysfunction in PCP can result in several human cancers. PCP can be readily assessed in the Drosophila eye, by the ordered ommatidial array shown below:

One of the key factors in the PCP pathway is the cell adhesion molecule called Fat. Using a combination of genetics and biochemistry, the McNeill (Mt. Sinai, Dept. Mol. Gen.) […]