Kelley lab screened for new pathways involved in the maintenance of mitochondrial DNA
In a paper recently published in Nature Chemical Biology, Simon Wisnovsky in Kelley laboratory describes a high-throughput screening study that leverages small-molecule probes to look for new DNA repair and replication factors in human mitochondria. The study uncovered a DNA polymerase that is essential for mitochondrial function that had never been observed in the organelle before. Given the importance of mitochondria as cellular energy generators and trigger points […]