Dysregulation of the human mitochondrial protease ClpP induces cancer cell death
Acyldepsipeptides (ADEPs) compounds have bactericidal properties via dysregulating the activity of the highly conserved tetradecameric bacterial ClpP protease. In a recent publication in Cell Chemical Biology, Keith S. Wong and co-authors from the Houry group have reported on the identification of ADEP analogs that are potent dysregulators of the human mitochondrial ClpP (HsClpP). These analogs interact with HsClpP at high affinity, causing the protease to non-specifically degrade model […]