Kamran Rizzolo

Houry Lab uncovers over 1000 novel interactions of chaperones in yeast

4 December 2017|

Kamran Rizzolo, in the laboratory of Professor Walid Houry, spoke with Faculty of Medicine’s writer Jim Oldfield about his lab’s recent  Cell Reports paper on the chaperone network in yeast.

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Mapping the molecular chaperone network

4 October 2017|

Rizzolo et al. from the Houry group provided a comprehensive view of molecular chaperone function in the cell through the use of a systematic global integrative network approach based on physical (protein-protein) and genetic (gene-gene or epistatic) interaction mapping. The analysis revealed the presence of a large chaperone functional supercomplex, which was named the NAJ chaperone complex, encompassing Hsp40, Hsp70, Hsp90, CCT and small Hsps. Many chaperones were found […]