Julien

SickKids scientists and collaborators identify structure of key malaria protein with blocking antibody

21 November 2018|

SickKids scientists have taken an important step forward on the path to finding effective biomedical interventions to halt the spread of malaria, a disease that affected an estimated 216 million people worldwide in 2016 alone.

Jean-Philippe Julien, Canada Research Chair in Structural Immunology, Assistant Professor in the Departments of Biochemistry and Immunology at the University of Toronto, and Scientist in the Molecular Medicine program at SickKids, and his colleagues […]

A picture of from left to right: Vivian Saridakis (York University), Justin Nodwell, Emil Pai, Oliver Ernst, Peter Lewis, Reinhart Reithmeier, JP Julien.

Emil Pai Symposium and Retirement

8 August 2018|

Emil F. Pai is retiring after more than 25 years at the University of Toronto. Emil joined the Departments of Biochemistry and Medical Genetics from the Max-Planck-Institute for Medical Research in Heidelberg in 1991 as a NSERC Industrial Research Chair following a global search for a renowned protein crystallographer to nucleate structural biology at the University of Toronto. Emil was already well-known for determining the first crystal structure of […]

Malaria: Cooperating antibodies enhance immune response

20 June 2018|

Source: Steve Bryson, PhD

Malaria is one of the most inflicting infectious diseases worldwide. Each year, an estimated 200 million people contract malaria and approximately 440,000 people succumb to the infectious disease.

Scientists in the Julien lab at The Hospital for Sick Children (SickKids) and their collaborators at the German Cancer Research Center (DKFZ) in Heidelberg, Germany, have studied how the human immune system combats malaria infections. In this […]

Crystallographers celebrate 1,000th protein structure

4 December 2017|

Scientists have solved 1,000 protein structures using data collected at the Canadian Light Source CMCF beamlines. The Canadian Light Source (CLS) is a national research facility, producing the brightest light in Canada. The Canada Foundation for Innovation, Natural Sciences and Engineering Research Council, National Research Council of Canada, Canadian Institutes of Health Research, the Government of Saskatchewan and the University of Saskatchewan fund the CLS operations, which allows hundreds […]

SickKids scientists obtain blueprint of molecular target for blood cancer and autoimmune therapies

4 October 2017|

Researchers at The Hospital for Sick Children (SickKids) have been exploring the molecular structure of immune cell components, and how gaining an understanding of their anatomical organization can help develop future targeted therapies for blood cancers and autoimmune diseases. Dr. Jean-Philippe Julien and co-authors, Dr. June Ereño-Orbea and Taylor Sicard provide the details of their study, “Molecular basis of human CD22 function and therapeutic targeting”, published October 2 in […]

Advanced protein engineering produces a candidate HIV vaccine prime immunogen - J Jardine C Corbaci

Banting Fellow in Julien lab contributes structure of immune hook that sets paradigm for HIV-1 vaccine testing in humans

24 March 2016|

A CIHR Banting Fellow in the Julien laboratory at the SickKids Research Institute, June Ereño-Orbea solved the crystal structure of an engineered HIV-1 immunogen, which brings the field one step closer to inducing broadly neutralizing antibodies (bnAbs) as a major HIV vaccine goal. This study, led by Bill Schief at The Scripps Research Institute and published in Science resolves a critical unmet challenge: to design a molecule that […]

trimer diversity simple phylogenetic shadow

PNAS article on HIV-1 clade C trimers that increase the arsenal of Env immunogens

8 September 2015|

Jean-Philippe Julien at the SickKids Research Institute and collaborators at Scripps report in PNAS two HIV-1 envelope glycoproteins (Env) of clade C sequences that are faithful antigenic and structural mimic of the native trimer in its pre-fusion conformation: the DU422 and ZM197M trimers. A cryo-EM reconstruction of the ZM197M trimer at sub-nanometer resolution revealed important conformational variability in loops that harbor high sequence diversity between HIV-1 clades. HIV-1 clade […]

Jean-Phillipe Julien: “Lowering the bar for an HIV vaccine”

18 February 2015|

Jean-Phillipe Julien, one of the newest members of the Biochemistry Department , presented the above lecture in our George Connell Seminar Series. For more on Professor Julien’s research visit his website.