Journal of Cell Biology

How to protect Peroxisomes and Mitochondria from Dying

6 February 2019|

The regulation of organelle abundance is critical for cell function and survival; however, the mechanisms responsible are not fully understood. Imbalances in organelle abundance can result in disease states, including Parkinson’s Disease resulting from dysregulated mitochondrial homeostasis. Peroxisome dysregulation also results in disease, most notably the Zellweger’s spectrum disorders. Although first considered to be caused exclusively by reduced peroxisome biogenesis, recently work shows that the most are due to increase […]

Avoiding catastrophe: Yeast study reveals clues to maintaining genome size

11 June 2018|

By Jovana Drinjakovic

Study reveals an unexpected role for a well- known protein machinery in maintaining the correct DNA content with implications for cancer and other diseases

As cells divide, they must accurately split their DNA between the two daughter cells or risk having an uneven number of chromosomes which can lead to developmental disorders and cancer. A new Donnelly Centre study uncovers how a […]

Malnutrition.

Study indicates malnutrition in children may lead to severe impairments in liver function

7 September 2016|

A group led by Peter Kim and Robert Bandsma (Paediatrics) made a breakthrough published in Journal of Cell Biology and in the Journal of Hepatology in linking peroxisome function through the gene PEX2 and the cell’s response to starvation.

Malnourished children living in the same household who are given the same food to eat sometimes have stark differences in health, leading researchers to query why some severely malnourished […]