john rubinstein

mitochondrial ATP synthase

Rubinstein Lab publishes paper in eLife

7 October 2015|

The Rubinstein laboratory, along with collaborators at the Howard Hughes Medical Institute’s Janelia Research Campus in Ashburn, Virginia, and Medical Research Council Mitochondrial Biology Unit in Cambridge, England, have just produced the highest-resolution structure available for the mitochondrial ATP synthase. Mitochondria are the ‘powerhouses’ of cells, and ATP synthase is the macromolecular machine that makes the cells supply of ATP, the currency of biochemical energy. Using new cryo-EM […]

Rubinstein Lab Nature Image

Rubinstein Lab captures V-ATPase images, paper published in Nature

19 May 2015|

V-ATPases are proton pumps that control the pH in many compartments within cells. V-ATPase activity is critical for the immune system (where acidic compartments in cells are used to destroy invading bacteria), cell growth (where compartments with different pHs are needed for molecules to be built and destroyed), the transmission of signals in the brain (where V-ATPases are needed to load packets of neurotransmitters that are deposited between neurons), […]