Houry

Functional cooperativity between the trigger factor chaperone and the ClpXP proteolytic complex

12 March 2021|

Rizzolo K, Yu AYH, Ologbenla A, Kim SR, Zhu H, Ishimori K, Thibault G, Leung E, Zhang YW, Teng M, Haniszewski M, Miah N, Phanse S, Minic Z, Lee S, Caballero JD, Babu M, Tsai FTF, Saio T, Houry WA.

In this manuscript, Walid A. Houry’s group identified a potential co-translational degradation pathway in Gram negative bacteria. A functional association […]

Development of antibiotics that dysregulate the Neisserial ClpP protease

1 March 2021|

In this highly collaborative effort, the groups of Walid A. Houry, Emil F. Pai, Robert A. Batey, and Scott D. Gray-Owen describe the generation and characterization of novel antibiotics targeting the bacterial ClpP protease.

Evolving antimicrobial resistance has motivated the search for novel targets and alternative therapies. Caseinolytic protease (ClpP) has emerged as an enticing new target since its function is conserved and […]