Development of antibiotics that dysregulate the Neisserial ClpP protease
In this highly collaborative effort, the groups of Walid A. Houry, Emil F. Pai, Robert A. Batey, and Scott D. Gray-Owen describe the generation and characterization of novel antibiotics targeting the bacterial ClpP protease.
Evolving antimicrobial resistance has motivated the search for novel targets and alternative therapies. Caseinolytic protease (ClpP) has emerged as an enticing new target since its function is conserved and […]