Professor Scott Prosser has been awarded the title of UofT Distinguished Professor of Biophysical Chemistry. This award recognizes individuals with highly distinguished accomplishments who exhibit and maintain an extraordinary level of activity in their research and scholarly work, and have achieved pre-eminence in their field in line with the University’s stated objectives and emerging priorities.
Congratulations!
Mechanistic Insights into Allosteric Regulation of the A2A Adenosine G protein-Coupled Receptor by Physiological Cations
Libin Ye1,2, Chris Neale3, Adnan Sljoka4, Brent Lyda5, Dmitry Pichugin1,2, Nobuyuki Tsuchimura4, Sacha T. Larda1,2, Régis Pomès2,6, Angel E. García3, Oliver P. Ernst2,7, Roger K. Sunahara5, R. Scott Prosser1,2,*
In a recent paper appearing in Nature Communications, Libin Ye (Prosser lab) and co-authors reveal the delicate balance between inactive states and activation intermediates by allosteric […]
Dr. Scott Prosser has received the 2017 Jeremy Knowles Award of the Royal Society of Chemistry.
Read the full story: http://www.rsc.org/ScienceAndTechnology/Awards/JeremyKnowlesAward/2017-winner.asp
Researchers in Prosser Lab and Pai Lab recently published in Science on the Role of Dimer Asymmetry and Protomer Dynamics in Enzyme Catalysis.
The associated YouTube video can be viewed here.
The dimeric enzyme fluoroacetate dehalogenase is one of only a handful of protein catalysts that can break the strongest bond in organic chemistry, the one between carbon and fluorine atoms, in the process transforming the highly toxic pesticide fluoroacetate into glycolate, a benign molecule. The laboratories of Emil Pai and Scott Prosser, together with the group of Régis Pomès and collaborators in the US and Japan, have […]