Dr. Clifford Lingwood – speaking at Discovery on Target
Dr. Clifford Lingwood will be talking at the Discovery on Target – Tackling Rare Diseases conference in September 2017. Read more about it here.
Lingwood Lab discover new approach to rescue endogenous misfolded proteins
Newly made proteins which do not quite achieve the correct 3D shape in the ER are moved to the cell cytoplasm via a specific membrane pore, and broken down. Many disease causing gene mutations e.g. in cystic fibrosis, also result in misfolding of the mutant protein, and its transport though this pore, for cytoplasmic degradation. This pore is hijacked by some bacterial toxins which need to access the cytoplasm to […]