Recent Graduates, Ruth Milkereit and Avinash Persaud, publish paper in Nature Communications
Mammalian Target of Rapamycin Complex 1 (mTORC1) is a master regulator of energy metabolism, protein synthesis, cell and animal growth, and it is implicated in numerous diseases, including cancer. Influx of essential amino acids such as Leu into cells is mediated by the LAT1-4F2hc (SLC7A5-SLC3A2) transporter in exchange for Gln, and results in the recruitment of the mTORC1 complex to the lysosomal membrane. Intracellular Leu then enters the lysosome to […]