23 March 2014|

The March 23rd issue of Nature Methods highlights the Stagljar Lab‘s development of the mammalian membrane two-hybrid (MaMTH) assay and its application to the human epidermal growth receptor (EGFR), mutations of which are associated with lung cancer. Using this approach, they identified CrkII as an interactor of the mutated EGFR and showed that Crk II regulates the stability of mutated EGFR and thus promotes signaling within […]