Phagocytosis of yeast (magenta) by a macrophage, together with actin staining (green). Image courtesy of Sergio Grinstein.
Signal transduction pathways regulate diverse processes in cell division, development, and differentiation. These pathways often involve cascades of protein kinases and their activation typically results in changes in gene expression and cellular activity.
Signal transduction research in the Department spans many fields: cell cycle regulation, morphogen signaling, pathogen-associated molecular patterns, signaling in the central nervous system, regulation of glucose and ion transport, signalling in blood platelets, and structural aspects of signaling molecules.
Our researchers make use of a number of model systems to relate the biochemical properties of signaling pathways to cellular function, including bacteria, yeast, mammalian cells and mouse models.
Faculty in the Department conducting research in this area:
Molecular mechanisms underlying intracellular signalling activated by the Wnt and Hedgehog families of secreted growth factors
Angers LabLeslie Dan Faculty of Pharmacy
144 College Street, Room 901
Toronto, ON
Dr. Stephane Angers
416-978-4939 stephane.angers@utoronto.ca
Morphogen signalling pathways and the regulation of complex biological responses
Attisano Lab160 College Street, room 1008
Dr. Liliana Attisano
416-946-3129 liliana.attisano@utoronto.ca
DNA Replication, DNA Damage and Genome Instability
Grant W. Brown LaboratoryDonnelly Centre, Room 1206
160 College Street
Dr. Grant W. Brown
416-946-5733 grant.brown@utoronto.ca
The Regulation of Signal Transduction by Phase Separated Biomolecular Condensates
Molecular Medicine
Hospital for Sick Children
Peter Gilgan Centre for Research and Learning (PGCRL)
Room 20-9710
686 Bay Street
Dr. Jonathon Ditlev
416-813-7654, ext. 309150 jonathon.ditlev@sickkids.ca
Transmembrane Signaling by GPCRs
Ernst LabMSB, Room 5316A
1 King's College Circle
Dr. Oliver P. Ernst
416-978-3849 oliver.ernst@utoronto.ca
Membrane Biology, Ion Transport, and the Innate Immune Response
Grinstein Lab555 University Ave.
Dr. Sergio Grinstein
416-813-5727 sergio.grinstein@sickkids.ca
The cytoskeleton as a cell fate-determining device
Kapus LabKeenan Centre for Biomedical Research
209 Victoria Street, Room 621
Dr. Andras Kapus
416-847-1751 KapusA@smh.ca
Cellular and biochemical basis of insulin action and insulin resistance: focus on glucose transport
Amira Klip LabThe Hospital for Sick Children
686 Bay Street Room 19.9-709
Dr. Amira Klip
416-813-6392 amira@sickkids.ca
Investigating the pathophysiology of atypical hemolytic-uremic syndrome caused by DGKE deficiency
Lemaire LabCell Biology Department
Peter Gilgan Centre For Research and Learning
SickKids Research Institute
686 Bay Street, room 19.9704
Dr. Mathieu Lemaire
416-813-7654 ext. 309419 mathieu.lemaire@sickkids.ca
Molecular Mechanisms of Cancer
The Ohh LabMaRS Centre, West Tower
661 University Avenue, Suite 1512
Dr. Michael Ohh
416-946-7922 michael.ohh@utoronto.ca
Biochemistry and function of the Nedd4 family of ubiquitin ligases
Rotin's labPGCRL, 19-9715,
686 Bay Street
Dr. Daniela Rotin
416-813-5098 drotin@sickkids.ca
Sunnybrook Research Institute
2075 Bayview Avenue, Room M7 617
Dr. Robert Screaton
416-480-6100 X 5743 robert.screaton@sri.utoronto.ca
Structural Biology of Eukaryotic Signal Transduction
Sicheri LabMount Sinai Hospital
600 University Avenue, Room 1090
Dr. Frank Sicheri
416 586-8471 sicheri@lunenfeld.ca
Interactome networks of integral membrane proteins and their roles in health & disease
The Stagljar LabDonnelly Centre
160 College Street
Dr. Igor Stagljar
1 416 946 7828 igor.stagljar@utoronto.ca
Membrane and Cytoskeleton Interaction
Trimble LabSickKids Research Institute
PGCRL Rm 199716
686 Bay Street
Dr. William S. Trimble
416-813-6889 wtrimble@sickkids.ca
Cell Division in Tumor Formation and Oogenesis
Wilde Lab661 University Ave
MaRS West Tower
Rm 1516
Dr. Andrew Wilde
416 946 7714 andrew.wilde@utoronto.ca