Spatio-temporal simulation examining the impact of co-localization on metabolic pathway efficiency. Individual coloured dots indicate individual proteins representing one of four classes of enzymes involved in consecutive steps in the glycolysis pathway, note how two sets of enzymes are constrained to the center of the ‘cell’. Substrate (orange) is introduced into one corner of the cell and rapidly diffuses throughout. Image was generated using Cell++ software developed in our department (Sanford et al. Bioinformatics 2006).
Projects for computationally oriented students are available in both our structural biology and informatics groups. With access to sophisticated computing platforms featuring tens of thousands of processors, faculty members develop and apply bioinformatics and modeling tools across a wide variety of research topics including:
- Sequencing and analyzing the genomes of phage, viruses, bacteria and parasites
- Modeling macromolecular structure and function
- Investigating the organization and dynamics of biochemical pathways
- Understanding the evolution of genes and genomes
- Identifying the relationships between a microbiome and its environment
Research labs in the Department currently seeking graduate students with a computer science background:
DNA Replication, DNA Damage and Genome Instability
Grant W. Brown LaboratoryDonnelly Centre, Room 1206
160 College Street
Dr. Grant W. Brown
416-946-5733 grant.brown@utoronto.ca
Structural Studies of Disordered Proteins
Forman-Kay labMolecular Medicine
Hospital for Sick Children
Peter Gilgan Centre for Research and Learning (PGCRL)
Room 20-9713
686 Bay Street
Dr. Julie D. Forman-Kay
416-813-5358 forman@sickkids.ca
Mechanisms of endothelial permeability
Lee LabSt. Michael's Hospital
LKS, Room 613
Dr. Warren L. Lee
416-864-6060-77656 warren.lee@unityhealth.to
Investigating the pathophysiology of atypical hemolytic-uremic syndrome caused by DGKE deficiency
Lemaire LabCell Biology Department
Peter Gilgan Centre For Research and Learning
SickKids Research Institute
686 Bay Street, room 19.9704
Dr. Mathieu Lemaire
416-813-7654 ext. 309419 mathieu.lemaire@sickkids.ca
Models for Cardiac and Neuronal Drug Toxicity and New Methods of Improving Cardiac Function
Maynes LabDepartment of Anesthesia and Pain Medicine
Hospital for Sick Children
555 University Ave
Dr. Jason T. Maynes
416-813-5934 jason.maynes@sickkids.ca
Membrane Protein Structural Biology
Moraes LabMaRS Center, West Tower
661 University Ave., Rm 1613
Dr. Trevor F. Moraes
416-946-3048 trevor.moraes@utoronto.ca
Parasites and Microbes in Health and Disease
Parkinson LabPeter Gilgan Center for Research and Learning
20th Floor, RM 20.9709
686 Bay Street
Dr. John Parkinson
416-813-5746 jparkin@sickkids.ca
Computational Studies of Biomolecular Structure and Function
Pomès LabPGCRL Room 21.9713
Hospital for Sick Children
686 Bay St
Dr. Régis Pomès
416-813-5686 pomes@sickkids.ca
Electron Cryomicroscopy of Macromolecular Machines
The Rubinstein LaboratoryRm. 20-9705
Peter Gilgan Centre for Research and Learning
The Hospital for Sick Children
686 Bay Street, Toronto
Dr. John L. Rubinstein
416-813-7255 john.rubinstein@utoronto.ca
4D Genomics in Development
Sawh LabMaRS, West Tower
661 University Ave
Dr. Ahilya N. Sawh
ahilya.sawh@gmail.com
Decoding the genomics and evolution of sleep
Sleep Evolution GroupRamsay Wright Laboratories,
25 Harbord St
Dr. Maxwell Shafer
max.shafer@gmail.com