Small molecule perturbation of protein and cell function has emerged as a powerful approach for elucidating biological and biochemical pathways. Through our links with the SPARC high throughput screening facility at the Peter Gilgan Centre for Research and Learning, many of our researchers are working to identify new chemical inhibitors and agonists. In addition to giving new insights into important biological systems this work can provide valuable lead compounds for drug discovery.
Students with an understanding of chemistry and inhibitor action will find unique opportunities to apply their knowledge in this research. Chemistry students will also fund unique opportunities in many of our structural biology groups.
Learning how to load a sample grid into the cryoelectron microscope
Research labs in the Department currently seeking graduate students with a chemistry background:
Peptide and Protein Structure in Membranes: From Folding to Drug Discovery
Deber labResearch Institute, The Hospital for Sick Children
Molecular Structure & Function
PGCRL, Room 20.9712
686 Bay Street
Dr. Charles M. Deber
416-813-5924 deber@sickkids.ca
Transmembrane Signaling by GPCRs
Ernst LabMSB, Room 5316A
1 King's College Circle
Dr. Oliver P. Ernst
416-978-3849 oliver.ernst@utoronto.ca
Structural Studies of Disordered Proteins
Forman-Kay labMolecular Medicine
Hospital for Sick Children
Peter Gilgan Centre for Research and Learning (PGCRL)
Room 20-9713
686 Bay Street
Dr. Julie D. Forman-Kay
416-813-5358 forman@sickkids.ca
Microbial Biofilm Formation: From Molecular Mechanisms to Therapeutics
Howell LabThe Hospital for Sick Children
Peter Gilgan Centre for Research and Learning (PGCRL)
Room 20-9715
686 Bay Street
Dr. P. Lynne Howell
416-813-5378 howell@sickkids.ca
NMR of Supra-Molecular Machines; Characterizing Low Populated States of Proteins
Kay LaboratoryMedical Sciences Building, Room 1233
1 King's College Circle
Dr. Lewis E. Kay
416-978-0741 kay@pound.med.utoronto.ca
Biological functions of glycosphingolipids
Lingwood LabRm 21-9707
Peter Gilgan Centre for Research and Learning
The Hospital for Sick Children
686 Bay Street
Dr. Clifford A. Lingwood
416 813 5998 cling@sickkids.ca
Models for Cardiac and Neuronal Drug Toxicity and New Methods of Improving Cardiac Function
Maynes LabDepartment of Anesthesia and Pain Medicine
Hospital for Sick Children
555 University Ave
Dr. Jason T. Maynes
416-813-5934 jason.maynes@sickkids.ca
Bacterial Toxin Pathogenesis: Molecular Mechanisms & Drug Discovery
Melnyk LabDr. Roman A. Melnyk
416-813-7654 ext. 328557 roman.melnyk@sickkids.ca
Membrane Protein Structural Biology
Moraes LabMaRS Center, West Tower
661 University Ave., Rm 1613
Dr. Trevor F. Moraes
416-946-3048 trevor.moraes@utoronto.ca
Chemical Communication and Warfare Among Microorganisms
Nodwell GroupMedical Sciences Building
1 King's College Circle
Dr. Justin Nodwell
Structural Studies of Virus Assembly
University of Toronto
MaRS Discovery Centre, West Tower
661 University Avenue
Dr. Michael Norris
416-946-7884 michael.norris@utoronto.ca
Computational Studies of Biomolecular Structure and Function
Pomès LabPGCRL Room 21.9713
Hospital for Sick Children
686 Bay St
Dr. Régis Pomès
416-813-5686 pomes@sickkids.ca
Structural Biology of Protein Complexes
Privé LabRoom 4-803 PMCRT
101 College Street
Dr. Gil Privé
416-581-7541 prive@uhnres.utoronto.ca
Using NMR to Investigate Protein Structure and Dynamics
Prosser LabUniversity of Toronto, Mississauga
South Building, Room
Dr. R. Scott Prosser
scott.prosser@utoronto.ca
Electron Cryomicroscopy of Macromolecular Machines
The Rubinstein LaboratoryRm. 20-9705
Peter Gilgan Centre for Research and Learning
The Hospital for Sick Children
686 Bay Street, Toronto
Dr. John L. Rubinstein
416-813-7255 john.rubinstein@utoronto.ca
Molecular-Level Study of Macromolecular Assemblies in Human Health and Disease
Sharpe LabPeter Gilgan Center for Research and Learning
686 Bay St., Room 20.9714
Dr. Simon Sharpe
416-813-7852 ssharpe@sickkids.ca
DNA Scissors, DNA Repair and Genome Stability
Wyatt LabMaRS Center, West Tower, Room 1521A
661 University Avenue
Dr. Haley Wyatt
416-978-4808 haley.wyatt@utoronto.ca
Fundamental Mechanisms of Molecular Self-Assembly
Yip Lab404 - 160 College St
Dr. Christopher M. Yip
416-978-7853 christopher.yip@utoronto.ca