Super-resolution microscopy of a centrosome labeled with antibodies recognizing pericentrin. Note the increase in resolution obtained with Structured Illumination Microscopy (SIM ~125 nm) and Stochastic Optical Reconstruction Microscopy (STORM ~25 nm) compared to regular widefield/deconvolution microscopy. Image: Vito Mennella
In addition to our strong focuses on biochemical and structural biological research, many of our investigators are pursuing questions of gene expression, developmental biology, neural function and other basic biological pathways and processes.
We have a large cohort of cell biologists as well as outstanding infrastructure for light and electron microscopy.
Research labs in the Department currently seeking graduate students with a biology background:
Molecular mechanisms underlying intracellular signalling activated by the Wnt and Hedgehog families of secreted growth factors
Angers LabLeslie Dan Faculty of Pharmacy
144 College Street, Room 901
Toronto, ON
Dr. Stephane Angers
416-978-4939 stephane.angers@utoronto.ca
Morphogen signalling pathways and the regulation of complex biological responses
Attisano Lab160 College Street, room 1008
Dr. Liliana Attisano
416-946-3129 liliana.attisano@utoronto.ca
Research in Cystic Fibrosis and Kidney Disease
The Bear LabThe Hospital for Sick Children
Peter Gilgan Centre for Research and Learning
686 Bay St.
Dr. Christine E. Bear
416-813-5981 bear@sickkids.ca
DNA Replication, DNA Damage and Genome Instability
Grant W. Brown LaboratoryDonnelly Centre, Room 1206
160 College Street
Dr. Grant W. Brown
416-946-5733 grant.brown@utoronto.ca
Bacteriophages
Davidson LabMaRS Centre, West Tower
661 University Ave., Room 1634
Toronto, ON
Dr. Alan R. Davidson
416-978-0332 alan.davidson@utoronto.ca
The Regulation of Signal Transduction by Phase Separated Biomolecular Condensates
Molecular Medicine
Hospital for Sick Children
Peter Gilgan Centre for Research and Learning (PGCRL)
Room 20-9710
686 Bay Street
Dr. Jonathon Ditlev
416-813-7654, ext. 309150 jonathon.ditlev@sickkids.ca
The Evolution of Microbial Disease
Ensminger Group661 University Avenue - MaRS West Tower
Room 1637
Dr. Alexander W. Ensminger
416-978-6522 alex.ensminger@utoronto.ca
Membrane Biology, Ion Transport, and the Innate Immune Response
Grinstein Lab555 University Ave.
Dr. Sergio Grinstein
416-813-5727 sergio.grinstein@sickkids.ca
MaRS West Discovery Tower, Suite 1600
661 University Ave
Toronto, ON
Dr. Lea Harrington
lea.harrington@utoronto.ca
Microbial Biofilm Formation: From Molecular Mechanisms to Therapeutics
Howell LabThe Hospital for Sick Children
Peter Gilgan Centre for Research and Learning (PGCRL)
Room 20-9715
686 Bay Street
Dr. P. Lynne Howell
416-813-5378 howell@sickkids.ca
Molecular characterization of antibody-antigen complexes to guide the design of next-generation vaccines and therapeutics
Julien laboratoryPeter Gilgan Centre for Research and Learning (PGCRL), Room 20-9703
686 Bay St.
Dr. Jean-Philippe Julien
416-813-7654, ext. 309424 jean-philippe.julien@sickkids.ca
Sequence/Structure/Function Relationships Determining the Elastomeric Properties of Elastin
Research Institute, The Hospital for Sick Children
PGCRL
686 Bay Street
Dr. Fred W. Keeley
416-813-6704 fwk@sickkids.ca
Cellular and biochemical basis of insulin action and insulin resistance: focus on glucose transport
Amira Klip LabThe Hospital for Sick Children
686 Bay Street Room 19.9-709
Dr. Amira Klip
416-813-6392 amira@sickkids.ca
Mechanisms of endothelial permeability
Lee LabSt. Michael's Hospital
LKS, Room 613
Dr. Warren L. Lee
416-864-6060-77656 warren.lee@unityhealth.to
Membrane-less Organelles and Neurodegeneration
Lee LabMaRS, West Tower, Suite 1521
661 University Ave.
Dr. Hyun Kate Lee
416-946-3813 hyunokate.lee-at-utoronto.ca
Investigating the pathophysiology of atypical hemolytic-uremic syndrome caused by DGKE deficiency
Lemaire LabCell Biology Department
Peter Gilgan Centre For Research and Learning
SickKids Research Institute
686 Bay Street, room 19.9704
Dr. Mathieu Lemaire
416-813-7654 ext. 309419 mathieu.lemaire@sickkids.ca
Biological functions of glycosphingolipids
Lingwood LabRm 21-9707
Peter Gilgan Centre for Research and Learning
The Hospital for Sick Children
686 Bay Street
Dr. Clifford A. Lingwood
416 813 5998 cling@sickkids.ca
Bacterial Toxin Pathogenesis: Molecular Mechanisms & Drug Discovery
Melnyk LabDr. Roman A. Melnyk
416-813-7654 ext. 328557 roman.melnyk@sickkids.ca
Membrane Protein Structural Biology
Moraes LabMaRS Center, West Tower
661 University Ave., Rm 1613
Dr. Trevor F. Moraes
416-946-3048 trevor.moraes@utoronto.ca
Chemical Communication and Warfare Among Microorganisms
Nodwell GroupMedical Sciences Building
1 King's College Circle
Dr. Justin Nodwell
Structural Studies of Virus Assembly
University of Toronto
MaRS Discovery Centre, West Tower
661 University Avenue
Dr. Michael Norris
416-946-7884 michael.norris@utoronto.ca
Molecular Mechanisms of Cancer
The Ohh LabMaRS Centre, West Tower
661 University Avenue, Suite 1512
Dr. Michael Ohh
416-946-7922 michael.ohh@utoronto.ca
Nuclear Export and Localization of mRNA
Palazzo LabMaRS, West Tower, Suite 1500
661 University Ave.
Dr. Alexander F. Palazzo
416-978-7234 alex.palazzo@utoronto.ca
Parasites and Microbes in Health and Disease
Parkinson LabPeter Gilgan Center for Research and Learning
20th Floor, RM 20.9709
686 Bay Street
Dr. John Parkinson
416-813-5746 jparkin@sickkids.ca
Biochemistry and function of the Nedd4 family of ubiquitin ligases
Rotin's labPGCRL, 19-9715,
686 Bay Street
Dr. Daniela Rotin
416-813-5098 drotin@sickkids.ca
Electron Cryomicroscopy of Macromolecular Machines
The Rubinstein LaboratoryRm. 20-9705
Peter Gilgan Centre for Research and Learning
The Hospital for Sick Children
686 Bay Street, Toronto
Dr. John L. Rubinstein
416-813-7255 john.rubinstein@utoronto.ca
4D Genomics in Development
Sawh LabMaRS, West Tower Rm 1632
661 University Ave
Dr. Ahilya N. Sawh
ahilya.sawh@utoronto.ca
Metabolic Diseases and Treatment
Schulze LabPeter Gilgan Center for Research and Learning
686 Bay Street
Dr. Andreas Schulze
647-813-7654 Ext 304831 andreas.schulze@sickkids.ca
Sunnybrook Research Institute
2075 Bayview Avenue, Room M7 617
Dr. Robert Screaton
416-480-6100 X 5743 robert.screaton@sri.utoronto.ca
Control of gene expression in the cytoplasm
Smibert labMaRS West Tower, 15th floor
661 University Ave
Dr. Craig A. Smibert
416-946-5538 c.smibert@utoronto.ca
Membrane and Cytoskeleton Interaction
Trimble LabSickKids Research Institute
PGCRL Rm 199716
686 Bay Street
Dr. William S. Trimble
416-813-6889 wtrimble@sickkids.ca
Cell Division in Tumor Formation and Oogenesis
Wilde Lab661 University Ave
MaRS West Tower
Rm 1516
Dr. Andrew Wilde
416 946 7714 andrew.wilde@utoronto.ca
DNA Scissors, DNA Repair and Genome Stability
Wyatt LabMaRS Center, West Tower, Room 1521A
661 University Avenue
Dr. Haley Wyatt
416-978-4808 haley.wyatt@utoronto.ca
Fundamental Mechanisms of Molecular Self-Assembly
Yip Lab404 - 160 College St
Dr. Christopher M. Yip
416-978-7853 christopher.yip@utoronto.ca