Mathieu Lemaire
Assistant Professor
MSc, McGill University, 2000
MD, McGill University, 2004
Paediatrics Residency, Yale University, 2014
| Address | Cell Biology Department Peter Gilgan Centre For Research and Learning SickKids Research Institute 686 Bay Street, room 19.9704 Toronto, ON M5G 0A4 |
| Lab | Lemaire Lab |
| Lab Phone | 416-813-7654 ext. 309452 |
| Office Phone | 416-813-7654 ext. 309419 |
| mathieu.lemaire@sickkids.ca |
Dr. Mathieu Lemaire finished his medical training at McGill University in 2004 and then moved to Toronto to learn Paediatrics at The Hospital for Sick Children. After completing his fellowship in Paediatric Nephrology in Toronto, he went to Yale University (New Haven, CT) to pursue a PhD in Investigative Medicine under the guidance of Dr Richard P. Lifton, with a focus on the genetics of rare paediatric kidney diseases. Dr Lemaire returned to the University of Toronto in 2014 as Assistant Professor of Paediatrics: he joined the Division of Nephrology at The Hospital for Sick Children as a Staff Physician, and the Cell biology Department within the SickKids Research Institute as Scientist-Track Investigator. He was cross-appointed to the Department of Biochemistry and to the Institute of Medical Sciences in 2015.
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Research Lab
My lab is located on the 19th floor of the PGCRL building. We are part of the Cell Biology program in the SickKids Research Institute.
CURRENT LAB MEMBERS
Dr Jing Wu, Lab Research Project Coordinator
Lisa Richardson, MSc student
ALUMNI
Lisa Richardson, Summer student (Guelph U)
Flora Shan, Summer student (UofT)
Learn more: Lemaire Lab
Research Description
Investigating the pathophysiology of atypical hemolytic-uremic syndrome caused by DGKE deficiency
The lab’s main aim is translational research that pertains to rare paediatric kidney diseases using genomic tools for gene discovery followed by careful functional dissection of candidate genes using cutting-edge microscopic, cell biology and biochemical methods.
The goal is to not only contribute to a better understanding of disease pathophysiology, but also aim to translate these findings into tangible changes in clinical care.
We have played a central role in the identification of the first non-complement gene that causes a recessive form of aHUS, diacylglycerol kinase epsilon. His laboratory continues to work on teasing out the mechanisms by which DGKE deficiency causes thrombosis restricted to small blood vessels of the kidneys. His team continues to do gene discovery on a variety of rare paediatric kidney diseases using whole-exome sequencing: functional work is on the way for yet another novel gene that causes complement-independent aHUS.
Courses Taught
BCH2104H The Biochemistry of Translational Medicine
BCH 2024H The Biochemistry of Translational Medicine
BCH449H Medical Biochemistry
Publications
View all publications on PubMed