Mathieu Lemaire

Mathieu Lemaire

Assistant Professor

MSc, McGill University, 2000
MD, McGill University, 2004
Paediatrics Residency, Yale University, 2014

Address Cell Biology Department
Peter Gilgan Centre For Research and Learning
SickKids Research Institute
686 Bay Street, room 19.9704

Toronto, ON M5G 0A4
Lab Lemaire Lab
Lab Phone 416-813-7654 ext. 309452
Office Phone 416-813-7654 ext. 309419

Dr. Mathieu Lemaire finished his medical training at McGill University in 2004 and then moved to Toronto to learn Paediatrics at The Hospital for Sick Children. After completing his fellowship in Paediatric Nephrology in Toronto, he went to Yale University (New Haven, CT) to pursue a PhD in Investigative Medicine under the guidance of Dr Richard P. Lifton, with a focus on the genetics of rare paediatric kidney diseases. Dr Lemaire returned to the University of Toronto in 2014 as Assistant Professor of Paediatrics: he joined the Division of Nephrology at The Hospital for Sick Children as a Staff Physician, and the Cell biology Department within the SickKids Research Institute as Scientist-Track Investigator. He was cross-appointed to the Department of Biochemistry and to the Institute of Medical Sciences in 2015.

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    Research Lab

    My lab is located on the 19th floor of the PGCRL building. We are part of the Cell Biology program in the SickKids Research Institute.



    Dr Jing Wu, Lab Research Project Coordinator

    Lisa Richardson, MSc student



    Lisa Richardson, Summer student (Guelph U)

    Flora Shan, Summer student (UofT)


    Learn more: Lemaire Lab

    Research Description

    Investigating the pathophysiology of atypical hemolytic-uremic syndrome caused by DGKE deficiency

    The lab’s main aim is translational research that pertains to rare paediatric kidney diseases using genomic tools for gene discovery followed by careful functional dissection of candidate genes using cutting-edge microscopic, cell biology and biochemical methods.

    The goal is to not only contribute to a better understanding of disease pathophysiology, but also aim to translate these findings into tangible changes in clinical care.

    We have played a central role in the identification of the first non-complement gene that causes a recessive form of aHUS, diacylglycerol kinase epsilon. His laboratory continues to work on teasing out the mechanisms by which DGKE deficiency causes thrombosis restricted to small blood vessels of the kidneys. His team continues to do gene discovery on a variety of rare paediatric kidney diseases using whole-exome sequencing: functional work is on the way for yet another novel gene that causes complement-independent aHUS.


    View all publications on PubMed