Jason De Melo

Assistant professor, teaching stream

Address

Medical Sciences Building
1 King's College Circle, Rm. 5221A
Toronto, ON M5S 1A8

Dr. De Melo (he/him) joined the Department of Biochemistry in August 2024 as an Assistant Professor, Teaching Stream. Dr. De Melo joined the department from McMaster University where he was an Assistant Professor in the School of Nursing, teaching biochemistry, metabolism, and pathophysiology.

Dr. De Melo’s career has provided him with extensive teaching, research, and writing experiences. His graduate studies focused on protein-protein interactions and the regulation of the tumour suppressor PTEN. After obtaining his Ph.D. from McMaster in 2014, he continued his training at the Princess Margaret Cancer Centre as a postdoctoral fellow, where his research focused on the post-translational regulation of the MYC protein. During this time he developed and taught a laboratory course on CRISPR gene editing, taught research methodology in the Faculty of Medicine at the University of Toronto, and led the development of a new training program for graduate students and postdoctoral fellows at UHN. Before returning to academia as an Assistant Professor, Dr. De Melo was a medical copywriter at Klick Health where he helped develop educational content on clinical trials and newly approved therapeutics for health care professionals.

Research Description

A full list of publications can be found on Google Scholar

Publications

Lysine-52 stabilizes the MYC oncoprotein through an SCFFbxw7-independent mechanism.
De Melo, J., Kim, S. S., Lourenco, C., & Penn, L. Z. (2017).
Oncogene, 36(49), 6815–6822. Read

MYC deregulation in primary human cancers.
Kalkat, M., De Melo, J., Hickman, K. A., Lourenco, C., Redel, C., Resetca, D., Tamachi, A., Tu, W. B., & Penn, L. Z. (2017).
In Genes (Vol. 8, Issue 6, pp. 2–30). Read

Enhancing Two-stage Collaborative Exams by Incorporating Immediate Feedback.
McCurdy, T., Volterman, K., Shiell, R., Zeadin, M., Dunn, K., De Melo, J., & Helli, P. (2017).
WCSE Proceedings, 1(1), Article 9. Read

Elevation of SIPL1 (SHARPIN) Increases Breast Cancer Risk.
De Melo, J., & Tang, D. (2015).
PLOS ONE, 10(5), e0127546. Read

SIPL1-facilitated PTEN ubiquitination contributes to its association with PTEN.
De Melo, J., Lin, X., He, L., Wei, F., Major, P., & Tang, D. (2014).
Cellular Signalling, 26(12), 2749–2756. Read