Frank Sicheri

Frank Sicheri


PhD, McMaster University, Daniel Yang Lab, 1989-1995
Postdoc, Rockefeller University, John Kuriyan Lab, 1995-1997

Address Mount Sinai Hospital
600 University Avenue, Room 1090
Toronto, ON M5G 1X5
Lab Sicheri Lab
Lab Phone 416 586-4800 ext 2336
Office Phone 416 586-8471

Dr. Frank Sicheri is Professor in the departments of Biochemistry and Molecular Genetics at the University of Toronto.

In the News

Research Lab

Research in the Sicheri Lab is focused on elucidating the mechanism of action of signalling molecules through the use of x-ray crystallography and biochemical techniques.

Learn more: Sicheri Lab

Research Description

Structural Biology of Eukaryotic Signal Transduction

Our research is directed at furthering the understanding of protein kinase regulation with a particular focus towards the underlying structural mechanism that imparts specificity to signalling function. We seek to uncover the structural basis for novel catalytic switching, substrate recognition and down-stream phosphoregulatory mechanisms. In addition, we are interested in uncovering the structure and function of new proteins and activities that impact protein kinase function. These efforts have recently led our lab into the area of ubiquitin directed proteolysis. Our long-term goal is to make use of what we learn about protein kinases and phosphoregulatory systems to develop drugs to treat human disease.

Lab Team Members

Derek CeccarelliDerek Ceccarelli Ph.D.
Senior Research Associate
Nicole DuffyNicole Duffy B.Sc.
Research Technician
Hao HuangHao Huang Ph.D.
Post Doctoral Fellow
Alexander Keszei
Alexander Keszei B.Sc.
Graduate Student
Zhiqin LiZhiqin Li B.Sc.
Research Technician
John LiJohn Li B.Sc
Graduate Student
Dan Mao
Dan Mao Ph.D.
Post Doctoral Fellow
Abiodun Ogunjimi
Abiodun A. Ogunjimi Ph.D.
Research Associate
Steve Orlicky
Steve Orlicky B.Sc.
Research Associate
Manisha Talukdar
Manisha Talukdar B.Sc.
Pre-graduate Student
Jean Tang
XiaoJing (Jean) Tang Ph.D.
Research Associate
Nero Thevakumaran
Nero Thevakumaran B.Sc.
Graduate Student
Leo WanLeo Wan B.Sc.
Graduate Student
Elton ZeqirajElton Zeqiraj Ph.D.
Post Doctoral Fellow

Awards & Distinctions

2011 — Royal Society of Canada Fellow
2009-present — Structural Biology of Signal Transduction, Canada Research Chair (CIHR- Tier 1)
2008 — Merck Frosst Prize, Canadian Society of Biochemistry and Molecular & Cellular Biology
2003 — Terry Fox Young Investigator Scholar National Cancer Institute of Canada / Terry Fox Foundation
1999-2004 — National Cancer Institute of Canada / Canadian Cancer Society Research Scientist Scholar
1998 — Premier’s Research Excellence Award, Ontario Research and Development Challenge Fund
1998 — Canada Foundation for Innovation Researcher
1996-1998 — Human Frontier Science Program, Postdoctoral Fellowship Award

Courses Taught

BCH 2110H Eukaryotic Signaling
BCH 2024H Eukaryotic Signaling
BCH374Y1 Research Project in Biochemistry
BCH473Y Advanced Research Project in Biochemistry


View all publications on PubMed