This course will cover the fundamentals of membrane proteomics from a structural, biochemical and genetic standpoint.  Among these will be cryo-EM, crystallography, NMR, and EPR methods as well as mammalian membrane two-hybrid screening and mass-spectrometry based methods.  A number of in vivo approaches to the discovery of drugs that modulate biological systems will also be covered.  Finally, the techniques used for the development of antibodies against membrane proteins with therapeutic potential will be introduced.

The course will be completed in a total of 12 hours in two-hour blocks, and will run over two weeks. In-class sessions will include lectures by professors and presentations by students on current literature. Classes will involve discussion of research papers.