Protein Trafficking in the Secretory and Endocytic Pathways


This course deals with the secretory and endocytic pathways of eukaryotic cells. It examines secreted and membrane proteins as they move from their site of synthesis in the endoplasmic reticulum (ER) through to the Golgi and the plasma membrane, or are sorted to intracellular organelles. The specific topics covered include protein translocation into the ER, chaperones and protein folding in the ER, retrotranslocation and protein degradation, the Unfolded Protein Response (UPR), vesicle biogenesis and ER to Golgi transport, regulated secretion, endocytosis and protein sorting in polarized cells.

Intracellular Transport Pathways: Compartments of the Secretory and Endosomal Pathways in Eukaryotic Cells. Szul, T. and Sztul, E. (2011) Physiology 26:348

Course Next Offered

This course is no longer offered in its current form. Effective January 2021 some aspects of this material will be covered in BCH440H - Protein Homeostasis


BCH210H/242Y, BCH311H/MGY311Y/PSL350H
Minimum cGPA of 2.8 required

Enrollment Limit

Yes — 50



Method of Student Evaluation

Quizzes: 12%
Mid-term test: 28% (1.5 hours; short answer)
Paper critique: 25%
Final exam: 35% (3 hours; short answer)

Additional Notes and Resources


James M. Rini

James M. Rini

MaRS Centre, West Tower, Rm 1614
661 University Ave


Last Updated 30 October 2020