Protein Homeostasis
BCH440H (BCH1440H)
Protein homeostasis is dependent on the coordinated synthesis, folding, localization and degradation of the thousands of proteins in a living cell. This course deals with selected aspects of the process including: i) protein folding in the cytoplasm and secretory pathway, ii) cytoplasmic, ER and mitochondrial chaperones, iii) protein quality control and degradation via the ubiquitin proteasome system, and iv) the unfolded protein response. The course will serve as a foundation for those with an interest in how cellular protein levels and conformations are maintained.
Course Next Offered
January 2025
Course Time and Location
Tuesdays/Thursdays, 10:00 am to 11:00 am, delivered in-person
MS 4171
Prerequisites
BCH210H1/BCH242Y1;BCH311H1/MGY311Y1/CSB349H1/PSL350H1
Enrollment Limit
Yes — 60
Method of Student Evaluation
Take Home Quizzes: 8% (2 X 4%)
Term test (2.0 hrs): 30%
Paper Critique I: 16%
Paper Critique II: 16%
Final Exam (2 hrs): 30%
Paper Critique: The research papers to be critiqued will be assigned at random. The critique should be a maximum of 2 pages single-spaced and include the following: i) a summary of the research question addressed, ii) the experimental approaches used, iii) the main results obtained, iv) any weaknesses in the paper noted and v) some follow-up questions and experiments.
