Protein Homeostasis

BCH440H (BCH1440H)

Protein homeostasis is dependent on the coordinated synthesis, folding, localization and degradation of the thousands of proteins in a living cell. This course deals with selected aspects of the process including: i) protein folding in the cytoplasm and secretory pathway, ii) cytoplasmic, ER and mitochondrial chaperones, iii) protein quality control and degradation via the ubiquitin proteasome system, and iv) the unfolded protein response. The course will serve as a foundation for those with an interest in how cellular protein levels and conformations are maintained.

Course Next Offered

January 2023

Course Time and Location

Tuesdays and Thursdays, 9:00 am to 10:00 am, in-person
HS 108, 155 College Street



Enrollment Limit

Yes — 50

Method of Student Evaluation

Take Home Quizzes: 8%
Term test (2.0 hrs): 30%
Paper Critique I: 16%
Paper Critique II: 16%
Final Assessment (2 hrs): 30%

The research paper to be critiqued will be assigned at random. The critique should be a maximum of 2 pages single-spaced and include the following: i) a summary of the research question addressed, ii) the experimental approaches used, iii) the main results obtained, iv) any weaknesses in the paper noted and v) some follow-up questions and experiments.

Additional Notes and Resources

BCH440 Syllabus, January 2023


James M. Rini

James M. Rini

MaRS Centre, West Tower, Rm 1614
661 University Ave


Last Updated 6 December 2022