Proteins: From Structure to Proteomics

BCH340H

COURSE SUMMARY

Proteins are the main functional units of the cell. In this course, a detailed overview of protein structure and function will be given with strong emphasis on the basic principles in the field. Students will be introduced to folded and intrinsically disordered proteins. Biophysical methods to study protein stability and folding will be discussed, as well as experimental approaches to determine protein structure and function. Students will be introduced to catalysis, kinetics, and the mechanisms that regulate enzyme activity. Finally, proteomic methods to studying protein networks in cells will be presented. The course will offer a solid basis in protein biochemistry. It is recommended for those interested in pursuing graduate studies or professional degrees in health or medicine.

 

LEARNING OUTCOMES

Students will learn fundamental principles about protein structure and function, as well as techniques that are used to study proteins in vitro and in cells. By integrating these concepts, students will conceptualize proteins as dynamic, three-dimensional molecules that specifically bind ligands to execute one or more critical roles in the cell. Students will apply this knowledge to critically analyze and discuss scientific literature, answer problem-based questions, and explain why abnormal protein structure and function can disrupt cellular homeostasis.

Course Next Offered

January 2024

Course Time and Location

Every Monday, Wednesday, and Friday from 1:10 pm – 2:00 pm
Room location is stated in the course Quercus

Prerequisites

BCH210H1/BCH242Y1 are mandatory. In addition, this course assumes you have a basic understanding of biology, chemistry, physics, and math.

Enrollment Limit

Yes — 60

Method of Student Evaluation

Enrolled students can refer to the course Quercus page for detailed information

Coordinator

Haley Wyatt

Haley Wyatt

MaRS Center, West Tower, Room 1521A
661 University Avenue
416-978-4808
haley.wyatt@utoronto.ca

Instructors

Last Updated 7 January 2024