Current Topics in Therapeutic Antibodies (previously called Engineering Vaccines: Development to Deployment)

BCH2109H

Significant advances in technologies related to antibody discovery and development have allowed therapeutic antibodies to become the fastest growing class of biopharmaceuticals over the last 20 years, with now over 100 FDA-approved antibody therapeutics. Anchored in historical examples of antibody development successes, this course will explore key concepts in the therapeutic antibody R&D pipeline, including 1) strategies to enhance natural antibodies (e.g. glycobiology, chemistry, protein engineering), 2) challenges and opportunities in discovery and developability, 3) therapeutic areas and mechanisms of action (MoA), and 4) targeted delivery and uses of antibody fragments in cell-based therapeutics. Topics for evaluation will focus on the emergence of new antigenic targets, and promising technologies for antibody therapeutic technologies of the future. You will acquire an understanding of antibody therapeutics from their development to deployment, and critically evaluate innovations that are required to overcome limitations of current technologies to pave the way for next-generation antibody therapeutics of global importance.

Non-Biochemistry Students:  This courses will be available to all non-Biochemsitry students to request through ACORN as follows:
Winter 2023 modules: December 1, 2022 – January 23, 2023 (last day to add Winter courses)

**Important note for non-Biochemistry students – if you have one unpaired BCH2024 course, then you must contact carrie.harber@utoronto.ca to sign up for the second 1/4 module as per the deadlines listed above.  Do not enroll through ACORN as your grades must be recorded under BCH 2024H Y – Focused Topic in Biochemistry.

Course Next Offered

Winter 2023

Course Time and Location

Dates / Times and Location:

February 28, 2023 14:00-16:00 – PGCRL Event room 3A and 3B
March 7, 2023 14:00-16:00– PGCRL Event room 2A and 2B
March 24, 2023 10:30-12:30 – PGCRL 11.9701
March 28, 2023 14:00-16:00 – PGCRL Event room 3A and 3B
April 4, 2023 14:00-16:00 – PGCRL Event room 2A and 2B
April 6, 2023 10:00-12:00 – PGCRL Event room 3A and 3B
April 6, 2023 14:00-16:00 – PGCRL Event room 3A and 3B

Evaluation Times
Dates: Apr 6
Time: 10-12pm and 2-4pm

Enrollment Limit

Yes — 18

Method of Student Evaluation

40%: Oral presentation – 5-slides TED Talk on selected topic
40%: Written assignment – 5-page review on selected topic
20%: Participation

Coordinator

Jean-Philippe Julien

Jean-Philippe Julien

Peter Gilgan Centre for Research and Learning (PGCRL), Room 20-9703
686 Bay St.
416-813-7654, ext. 309424
jean-philippe.julien@sickkids.ca

Last Updated 1 February 2023