The Biochemistry of Translational Medicine

BCH2104H

This course will focus on reviewing scientific articles that use biochemistry and/or cell biology to help better understand human diseases. Emphasis will be on published scholarly work that provides examples of translational medicine or “bench-to-bedside” approach, which aims to expedite the discovery of new diagnostics and treatments.

– The first session will be an intro by both of us (~1h) followed by a discussion led by us about a paper (~1h).

– The intro will include some tips on how to present an article, etc.

– The other sessions will be 2 x 1 h sessions where one student presents a recent paper that provides an exciting example of an application of biochemistry to translational medicine (a second student will present another article during the second hour).

– Each student will be free to choose an article themselves or use one from the bank of articles provided by us (typically a very recent article published in of-of the top journals, such as Cell, Science, Nature, Nat Med, Nat Genetics, JCI, Sci Translat Med, etc.).

– Each student will also have to provide a short write-up (max 250 words) about the article presented that would be an abstract that could be read by a layperson (i.e., grade 7-8 education) + a relevant title. This is an important exercise because it is required for most grants that anyone submits.

– The format delineated above may need to be slightly amended depending on the number of students who end up enrolling for the class and do not withdraw.

Non-Biochemistry Students:  This courses will be available to all non-Biochemsitry students to request through ACORN as follows:
Fall 2022 modules: September 1, 2022 – September 26, 2022(last day to add Fall courses)

**Important note for non-Biochemistry students – if you have one unpaired BCH2024 course, then you must contact carrie.harber@utoronto.ca to sign up for the second 1/4 module as per the deadlines listed above.  Do not enroll through ACORN as your grades must be recorded under BCH 2024H Y – Focused Topic in Biochemistry.

Course Next Offered

Fall 2022 (Oct - Dec)

Course Time and Location

Start Date: Oct 25
End Date: Dec 13
Time: 2-4 pm

Day(s) of the Week: Tuesday
Note: We will likely only need 6 or 7 out of the 8 Tuesdays included in this time frame.

Course Location:
Building: Virtual or SickKids Research Institute (PGCRL; 686 Bay street)
Room: TBC

Enrollment Limit

Yes — 10

Method of Student Evaluation

Marks will be derived from:
- journal club presentation (70%)
- participation in other students’ presentations (20%)
- lay abstract (10%)

Coordinator

Mathieu Lemaire

Mathieu Lemaire

Cell Biology Department
Peter Gilgan Centre For Research and Learning
SickKids Research Institute
686 Bay Street, room 19.9704

416-813-7654 ext. 309419
mathieu.lemaire@sickkids.ca

Aleixo Muise

Aleixo Muise

PGCRL Tower
19.9400, J-Me
72 Elm Street
416-813-7735 or 416-813-5216
aleixo.muise@sickkids.ca

Last Updated 3 August 2022