Membrane Proteomics in Biomedical Research

BCH 2024H

This course will cover the fundamentals of membrane proteomics from a structural, biochemical and genetic standpoint. Among these will be cryo-EM, crystallography, NMR, and EPR methods as well as mammalian membrane two-hybrid screening and mass-spectrometry based methods. A number of in vivo approaches to the discovery of drugs that modulate biological systems will also be covered. Finally, the techniques used for the development of antibodies against membrane proteins with therapeutic potential will be introduced.

The course will be completed in a total of 12 hours in two-hour blocks, and will run over two weeks. In-class sessions will include lectures by professors and presentations by students on current literature. Classes will involve discussion of research papers.

**THIS COURSE WILL BE ONLINE ONLY**

SIGN UP: Please click HERE to request this course.

**THIS COURSE WILL BE ONLINE ONLY**

Add date – Deadline to submit request – November 11, 2020
Drop date – Students have until the day before the first class to drop the course. Students can only drop the course after the first class with the permission of the instructor.

Molecular Genetics Students: Enrollment in this module must be done through your Graduate Administrator. Please contact them for further details.

Course Next Offered

Fall 2020 (Nov)

Course Time and Location

Monday Nov 16, Wednesday Nov 18, Thursday Nov 19,
Monday Nov 23, Wednesday Nov 25, Friday Nov 27

Time: 10:00 am - 12:00 pm
Location: Zoom online

Monday, Nov 16, 2020, Oliver Ernst, “Tackling G-protein-coupled receptors proteins by crystallography, cryo-EM and EPR”

Wednesday, Nov 18, 2020, Scott Prosser, “Ligand and fragment screening of membrane receptors by NMR”

Thursday, Nov 19, 2020, Claudiu Gradinaru, “Making sense of biology by counting molecules”

Monday, Nov 23, 2020, Igor Stagljar, “Exploiting Mammalian Membrane Two-Hybrid (MaMTH) Assay for Target Identification and Drug Discovery”

Wednesday, Nov 25, 2020, Sachdev Sidhu, "Synthetic antibodies for clinically relevant membrane proteins"

Friday Nov 27, 2020, Mikko Taipale, "Exploiting toxins for receptor discovery"