About Mathieu Lemaire
Brief Biography
Dr. Mathieu Lemaire finished his medical training at McGill University in 2004 and then moved to Toronto to learn Paediatrics at The Hospital for Sick Children. Following a fellowship in Nephrology in Toronto, he went to Yale University (New Haven, CT) to pursue a PhD in Investigative Medicine under the guidance of Dr Richard P. Lifton, with a focus on the genetics of rare paediatric kidney diseases. Dr Lemaire returned to the University of Toronto in 2014 as Assistant Professor of Paediatrics: he joined the Division of Nephrology at The Hospital for Sick Children as a staff physician, and the SickKids Research Institute as Scientist-Track Investigator.
Laboratory website
TBA
Clinical Care Activities
Staff physician in the Division of Nephrology (The Hospital for Sick Children).
Research Interests
My main interest is to do translational research that pertains to rare paediatric kidney diseases using genomic tools for gene discovery followed by careful functional dissection of candidate genes using cutting edge microscopic, cell biology and biochemical methods. At the moment, our main focus is atypical hemolytic-uremic syndrome (HUS).
- We recently identified the first non-complement genes that causes a recessive form of atypical HUS, diacylglycerol kinase epsilon (DGKE; Lemaire et al., Nature Genetics, 2013). We are working to tease out how DGKE loss-of-function causes thrombosis that is restricted to small calibre vessels of infant’s kidneys.
- We are continuing to perform gene discovery on a variety of rare paediatric kidney diseases using whole-exome sequencing.
We hope that our results will not only contribute to a better understanding of atypical HUS, but will also translate into tangible changes in clinical care within a reasonable time frame.
Peer-reviewed Publications
1. Lemaire M, Chase R. Olfactory Orientation in the Land Snail Helix Aspersa. J. Comp. Phys. A 182, 81–87 (1998).
2. Zalunardo N, Lemaire M, Davids MR, Halperin ML. Acidosis in a patient with cholera: a need to redefine concepts. Quart. J. Med. 2004;97(10):681–96.
3. Lemaire M, Kantor P, Manson D, Grasemann H, Ely BA, Nield LS, Michalik DE, Batra J. Pediatr Rev. 2008;29(11):399–406.
4. Lemaire M, Diamond IR, Langer JC. Whole or parts—the fate of hemoperitoneum. Surgery. 2009;146(5):947–9
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5. Lemaire M. et al. A novel disease-causing mutation in AVPR2: Q96H. Nephr. Dial. Transplant. Plus 1, 200–222 (2009).
6. Lemaire M et al. Treatment of vancomycin intoxication using hemodialysis with a high-flux membrane: case report and review of the literature. Nephr. Dial. Transplant. Plus 3, 260–264 (2010).
7. Lemaire M, Islam QS, Shen H, Khan MA, Parveen M, Abedin F, Haseen F, Hyder Z, Cook RJ, Zlotkin SH. Iron-containing micronutrient powder (iMNP) provided to children with moderate-to-severe malnutrition increased hemoglobin but not infectious morbidity risk: A randomized, double-blind, placebo-controlled, non-inferiority safety trial. Am J Clin Nutr. 2011;94(2):585–93.
8. Lemaire M, Frémeaux-Bacchi V, Schaefer F, Choi M, Tang WH, Le Quintrec M, Fakhouri F, Taque S, Nobili F, Martinez F, Ji W, Overton JD, Mane SM, Nürnberg G, Altmüller J, Thiele H, Morin D, Deschenes G, Baudouin V, Llanas B, Collard L, Majid MA, Simkova E, Nürnberg P, Rioux-Leclerc N, Moeckel GW, Gubler MC, Hwa J, Loirat C, Lifton RP. Recessive mutations in DGKE cause atypical hemolytic-uremic syndrome. Nat Genet. 2013;45(5):531–6.
Writings as associate scientific advisor, Science Translational Medicine
1. Lemaire M. PGE2—The Immune System Tamer. Sci Transl Med 30 April 2014. 6:234ec75. DOI:10.1126/scitranslmed.3009255.
2. Lemaire, M. WANTED: Natural-Born Sickler. Sci Transl Med 11 June 2014. 6:240ec101. DOI:10.1126/scitranslmed.3009588.
3. Lemaire, M. For IBD, Bugs and Genes Are the Name of the Game. Sci Transl Med 23, July 2014 6:246ec126. DOI:10.1126/scitranslmed.3009812.
4. Lemaire M. Human cells: Finally Open for Cancer Business. Sci Transl Med 3, September 2014 6:252ec150. DOI: 10.1126/scitranslmed.3010262.
5. Lemaire M. Superheroes and Villains of the Heart. Sci Transl Med 15 October 2014 6:258ec175. DOI:10.1126 scitranslmed.aaa0483.
Book Chapters
1. Lemaire M. & Frémeaux-Bacchi V. Chapter 45: HUS, TTP & other thrombotic microangiopathies. In Genetic Diseases of the Kidney, 2nd Edition. Editors: Lifton R., Somlo S., Giebisch G., Seldin D., and Pollak M. Elsevier, (tentatively scheduled to be published in 2014).
2. Lemaire M. & Waters A. Chapter 4: Genetics: Basic Concepts and Testing. In Comprehensive Pediatric Nephrology, 2nd Edition. Editors: Geary D.F., & Schaefer F. Mosby, (tentatively scheduled to be published in 2014).
3. Lemaire M., Radhakrishnan, S., & Licht C. Chapter 16: Fluid, Electrolytes and Acid-Base. In Hospital for Sick Children Handbook, 11th Edition. Editors: Dipchand A.I., Friedman J.N., Gupta, S., Bismilla Z., & Lam C. Elsevier, 2009.
