SLx4 complexes from EMBO Journal article

SLx4 complexes from EMBO Journal article

Slx4 is a nuclease scaffold protein that is mutated in Fanconi Anemia patients. In his study, published in the EMBO Journal, Attila and colleagues in Grant Brown’s lab defined the pathway that assembles Slx4 protein complexes onto chromatin when DNA replication is blocked by DNA damaging drugs. Surprisingly, Slx4 complexes promote checkpoint signaling to allow cells to resist and repair DNA damage. Attila’s study, funded by the Canadian Cancer Society Research Institute, provides the first view of signaling complexes at damaged DNA replication forks.

The paper is available online