Research in the Moraes Lab examines protein and ion translocation across bacterial membranes. In particular, Dr. Moraes dissects the components of these pathways examining their interactions in molecular detail. Biochemical tools such as X-ray crystallography provide atomic resolution 3D-models of the proteins, while surface plasmon resonance, isothermal calorimetry or bio-layer interferometry are used to determine kinetic parameters and validate models that describe the mechanism of action. These membrane proteins function together as a complexes to facilitate efficient transport that is essential for pathogenic bacteria to survive within the host, thus this research provides the basis for developing novel antimicrobial therapeutics.
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