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Circular Dichroism Spectroscopy.

The Centre for Advanced Protein Science allows scientists from various disciplines to use, apply, and develop a full range of state-of-the-art biophysical technologies to obtain a molecular description of the folding, structure, dynamics and function of protein molecules.

Some instruments are suited for the characterization of protein structure and stability such as the circular dichroism spectropolarimeter and the differential scanning calorimetry, while others are suited for the study of protein-protein and protein-ligand interactions such as the Biacore and the isothermal titration calorimeter. The instruments are available for use by the members of the general Toronto scientific community.

Equipment

  • Circular dichroism spectropolarimeter – for protein structure studies
  • Spectrofluorometer – for protein structure and protein-ligand interaction studies
  • UV/VIS Spectrophotometer – for protein structure and protein-ligand interaction studies
  • Analytical ultracentrifuge
  • MALDI-ToF mass spectrometer – to determine molecular mass of proteins and peptides
  • Peptide arrayer – to generate many peptides and array them on a membrane
  • Isothermal titration calorimetry – for protein-ligand and protein-protein interaction studies
  • Differential scanning calorimetry – to study protein stability
  • Biacore – for protein-ligand and protein-protein interaction studies
  • Plate Reader – to determine enzyme kinetics

 

ULTRA

Beckman Optima XL-A Analytical Ultracentrifuge

Analytical Ultracentrifugation Service

Locations

Medical Sciences Building, Rooms 5308 and 5313

Funding

Instruments obtained through funds from CIHR, CFI, and Department of Biochemistry.

 

Coordinator and Contact

Walid A. Houry

Walid A. Houry

1 King's College Circle
Medical Sciences Building, Room 5308
416-946-7141
walid.houry@utoronto.ca