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A novel potential approach to treat cancer: Targetting NUAK2 to block oncogenic YAP/TAZ signaling during tumorigenesis

 

Time-lapse imaging of Clover-YAP WT (first movie) and 5SA (second movie) in MDA-MB231 cells. Localization of Clover-YAP WT (wild type) and 5SA (mutant at all five LATS targeting sites) was monitored before and after addition of NUAK2 specific inhibitor, WZ4003. Note that the nuclear signal is gradually lost after addition of WZ4003 in cells expressing YAP-WT but not affected in YAP-5SA. Images were captured every 10 min for 2 hours. […]

3 October 2018|

BCH2024H Effective Science Communication

To be taken by all new grad students. Classes are Wednesdays 2:30-4PM before Grad Seminar. For  class dates, locations and times, see below.

This student-centered class will allow graduate students to mature into effective science communicators and help them to form a coherent peer group.

 

For year 2018

 

Class 1 (2:30-4PM MSB 5231) – Sept 12

How to get […]

9 September 2015|

Attisano lab discovers a new player in the Hippo signalling pathway

The Hippo pathway is a conserved intracellular signaling pathway with important roles in various aspects of development and homeostasis in animals. Defects in Hippo pathway regulation are associated with various types of cancers. Factors such as cell-cell contact, cell morphology and G-protein coupled receptors have been shown to regulate the Hippo pathway but the mechanisms are not very well understood.

In work published in the latest edition of the EMBO Journal, the Attisano lab describe a new regulator of this pathway, ARHGEF7 (also known as β-Pix). […]

19 December 2014|

Biochemistry Graduate Student Survey 2013-14

The annual Graduate Student Survey is announced on the BGSU blog:

Please let us know how you are doing in your program and how you think the department is doing.

The survey will take approximately 15 minutes and covers topics including: stipend/finances, time to completion, and social events. This year we’re happy to provide a dedicated course feedback section. If you’ve taken a biochemistry course this year, use this opportunity to voice your opinion on the class. […]

24 April 2014|