Networks in protein sequence space, based on a biophysical model that has been applied extensively in the study of protein evolution. The image here shows a supernet of sequences (background) that is made up of interconnecting neutral nets (top). Neutral nets are often superfunnels, or basins of attraction in evolution (middle). The bottom drawing shows a real-life example conformational switches between two superfunnels.  Image created by Tobias Sikosek and Hue Sun Chan.

Networks in protein sequence space, based on a biophysical model that has been applied extensively in the study of protein evolution. The image here shows a supernet of sequences (background) that is made up of interconnecting neutral nets (top). Neutral nets are often superfunnels, or basins of attraction in evolution (middle). The bottom drawing shows a real-life example of conformational switches between two superfunnels. Image created by Tobias Sikosek and Hue Sun Chan.

Biochemical research programs are becoming increasingly reliant on adopting computer-based approaches. Of particular significance is the integration and visualization of so-called “big data”‘ – datasets ranging from tens of terabytes to petabytes associated with the recent emergence of metabolomic and next-generation sequencing platforms.

With access to sophisticated computing platforms featuring tens of thousands of processors, many faculty members develop and apply bioinformatics and modelling tools across a wide variety of research topics including:

  • Sequencing and analysing the genomes of phage, viruses, bacteria and parasites
  • Modeling macromolecular structure and function
  • Investigating the organization and dynamics of biochemical pathways
  • Understanding the evolution of genes and genomes
  • Identifying the relationships between a microbiome and its environment

 

Faculty in the Department conducting research in this area:

Grant W. Brown Laboratory

DNA Replication, DNA Damage and Genome Instability

Grant W. Brown Laboratory

Donnelly Centre, Room 1206
160 College Street

Dr. Grant W. Brown


416-946-5733   grant.brown@utoronto.ca

Chan Research Group

Theoretical and Computational Investigations of Protein Folding, Interactions, and Evolution

Chan Research Group

MSB 5363
1 King's College Circle

Dr. Hue Sun Chan


416-978-2697   chan@arrhenius.med.utoronto.ca

Davidson Lab

Bacteriophages

Davidson Lab

MaRS Centre, West Tower
661 University Ave., Room 1634
Toronto, ON

Dr. Alan R. Davidson


416-978-0332   alan.davidson@utoronto.ca

Ensminger Group

The Evolution of Microbial Disease

Ensminger Group

MSB Room 4261
1 King's College Circle

Dr. Alexander W. Ensminger


416-978-6522   alex.ensminger@utoronto.ca

Forman-Kay lab

Structural Studies of Disordered Proteins

Forman-Kay lab

Molecular Structure and Function
Hospital for Sick Children
Peter Gilgan Centre for Research and Learning (PGCRL)
Room 20-9713
686 Bay Street

Dr. Julie D. Forman-Kay


416-813-5358   forman@sickkids.ca

Lemaire Lab

Cell Biology Department
Peter Gilgan Centre For Research and Learning
SickKids Research Institute
686 Bay Street, room 19.9704

Dr. Mathieu Lemaire


416-813-7654 ext. 309419   mathieu.lemaire@sickkids.ca

Maynes Lab

Models for Cardiac and Neuronal Drug Toxicity and New Methods of Improving Cardiac Function

Maynes Lab

Department of Anesthesia and Pain Medicine
Hospital for Sick Children
555 University Ave

Dr. Jason T. Maynes


416-813-5934   jason.maynes@sickkids.ca

Moraes Lab

Membrane Protein Structural Biology

Moraes Lab

Rm 5366 Medical Sciences Building
1 King's College Circle

Dr. Trevor F. Moraes


416-946-3048   trevor.moraes@utoronto.ca

Parkinson Lab

Parasites and Microbes in Health and Disease

Parkinson Lab

Peter Gilgan Center for Research and Learning
20th Floor, RM 20.9709
686 Bay Street

Dr. John Parkinson


416-813-5746   jparkin@sickkids.ca

Pomès Lab

Computational Studies of Biomolecular Structure and Function

Pomès Lab

PGCRL Room 21.9713
Hospital for Sick Children
686 Bay St

Dr. Régis Pomès


416-813-5686   pomes@sickkids.ca

Steipe Lab

Bioinformatics

Steipe Lab

Medical Sciences Building, 5271
1 King's College Circle

Dr. Boris Steipe


(416) 946-7741   boris.steipe@utoronto.ca

Yip Lab

Fundamental Mechanisms of Molecular Self-Assembly

Yip Lab

404 - 160 College St

Dr. Christopher M. Yip


416-978-7853   christopher.yip@utoronto.ca