Glycolysis

Spatio-temporal simulation examining the impact of co-localization on metabolic pathway efficiency. Individual coloured dots indicate individual proteins representing one of four classes of enzymes involved in consecutive steps in the glycolysis pathway, note how two sets of enzymes are constrained to the center of the ‘cell’. Substrate (orange) is introduced into one corner of the cell and rapidly diffuses throughout. Image was generated using Cell++ software developed in our department (Sanford et al. Bioinformatics 2006).

Projects for computationally oriented students are available in both our structural biology and informatics groups. With access to sophisticated computing platforms featuring tens of thousands of processors, faculty members develop and apply bioinformatics and modeling tools across a wide variety of research topics including:

  • Sequencing and analyzing the genomes of phage, viruses, bacteria and parasites
  • Modeling macromolecular structure and function
  • Investigating the organization and dynamics of biochemical pathways
  • Understanding the evolution of genes and genomes
  • Identifying the relationships between a microbiome and its environment

Research labs in the Department currently seeking graduate students with a computer science background:

Grant W. Brown Laboratory

DNA Replication, DNA Damage and Genome Instability

Grant W. Brown Laboratory

Donnelly Centre, Room 1206
160 College Street

Dr. Grant W. Brown


416-946-5733   grant.brown@utoronto.ca

Forman-Kay lab

Structural Studies of Disordered Proteins

Forman-Kay lab

Molecular Medicine
Hospital for Sick Children
Peter Gilgan Centre for Research and Learning (PGCRL)
Room 20-9713
686 Bay Street

Dr. Julie D. Forman-Kay


416-813-5358   forman@sickkids.ca

Lee Lab

Mechanisms of endothelial permeability

Lee Lab

St. Michael's Hospital
LKS, Room 613

Dr. Warren L. Lee


416-864-6060-77656   leew@smh.ca

Lemaire Lab

Cell Biology Department
Peter Gilgan Centre For Research and Learning
SickKids Research Institute
686 Bay Street, room 19.9704

Dr. Mathieu Lemaire


416-813-7654 ext. 309419   mathieu.lemaire@sickkids.ca

Maynes Lab

Models for Cardiac and Neuronal Drug Toxicity and New Methods of Improving Cardiac Function

Maynes Lab

Department of Anesthesia and Pain Medicine
Hospital for Sick Children
555 University Ave

Dr. Jason T. Maynes


416-813-5934   jason.maynes@sickkids.ca

Moraes Lab

Membrane Protein Structural Biology

Moraes Lab

Rm 5366 Medical Sciences Building
1 King's College Circle

Dr. Trevor F. Moraes


416-946-3048   trevor.moraes@utoronto.ca

Parkinson Lab

Parasites and Microbes in Health and Disease

Parkinson Lab

Peter Gilgan Center for Research and Learning
20th Floor, RM 20.9709
686 Bay Street

Dr. John Parkinson


416-813-5746   jparkin@sickkids.ca

Pomès Lab

Computational Studies of Biomolecular Structure and Function

Pomès Lab

PGCRL Room 21.9713
Hospital for Sick Children
686 Bay St

Dr. Régis Pomès


416-813-5686   pomes@sickkids.ca

The Rubinstein Laboratory

Electron Cryomicroscopy of Macromolecular Machines

The Rubinstein Laboratory

Rm. 20-9705
Peter Gilgan Centre for Research and Learning
The Hospital for Sick Children
686 Bay Street, Toronto

Dr. John L. Rubinstein


416-813-7255   john.rubinstein@utoronto.ca