Khosrow Adeli

Khosrow Adeli

Professor

MSc, Biochemistry, University of Ottawa, 1982
PhD, Biochemistry, University of Ottawa, 1986
Postdoc, Clinical Biochemistry, University of Toronto, 1988

Address 555 University Ave
Toronto, ON M5G1X8
Lab Adeli Lab
Lab Phone 416-813-7654 x308754
Office Phone 416-813-8682
Email khosrow.adeli@sickkids.ca

Khosrow Adeli is currently a Senior Scientist in the Program in Molecular Structure and Function, Research Institute, The Hospital for Sick Children, University of Toronto. He is also the head and full professor of Clinical Biochemistry at the Hospital for Sick Children and the Departments of Biochemistry, and Laboratory Medicine & Pathobiology at the University of Toronto in Toronto, Canada. He is the Director of Point of Care Testing program at the Hospital for Sick Children in Toronto.

Dr. Adeli is a fellow of the Canadian Academy of Clinical Biochemistry and a diplomate of the American Board of Clinical Biochemistry. He is currently the Editor-in-Chief of the Critical Reviews in Clinical Laboratory Sciences. Dr. Adeli served as the Editor-in-Chief of the Clinical Biochemistry journal for 7 years (1999-2006). He is an editorial board member of the Clinical Biochemist Reviews. He served (2006-2010) as the President of COMACC, the Commission on Accreditation in Clinical Chemistry, a North American organization responsible for accreditation of clinical chemistry training programs in the USA and Canada. He currently serves as the Chair of Publications and Communications Division of the International Federation of Clinical Chemistry (IFCC).

Dr. Adeli has been actively involved in both basic and clinical laboratory research since 1988 and has published over 250 articles and abstracts in the field of lipid and lipoprotein metabolism, diabetic dyslipidemia, and metabolic disorders. He has received several national and international awards for research excellence including the 2014 Distinguished Service Award of the University of Toronto, the 2011 Canadian Society of Atherosclerosis, Thrombosis and Vascular Biology (CSATVB) Scientific Excellence Award, the 2008 Merck Senior Investigator Award of the Canadian Lipoprotein Conference, the 2006 Canadian Society of Clinical Chemistry National Award for outstanding contributions to clinical chemistry, 2004 Canadian Academy of Clinical Biochemistry National Award, and the 1999 Canadian Society of Clinical Chemistry Research Excellence Award. He has also been active in clinical chemistry research and is the principal investigator of the CALIPER (Canadian Laboratory Initiative on Pediatric Reference Interval Database) project aimed at the establishment of a laboratory reference interval database for biomarkers of pediatric disease.

Research Lab

Very Low Density Lipoprotein (VLDL) Surface View

The incidences of insulin-resistant states such as obesity and type 2 diabetes have been increasing at an alarming rate in recent years in both paediatric and adult populations. Dr Khosrow Adeli’s research program aims to elucidate the key genetic and environmental factors that link insulin resistance, lipoprotein abnormalities, and cardiovascular disease.

Dr. Adeli is investigating the underlying cellular and molecular mechanisms of the development of metabolic dyslipidaemia in insulin-resistant states. Using diet-induced animal models of insulin resistance and obesity, he is investigating the link between the insulin signaling pathway and deregulation of hepatic and intestinal lipoprotein metabolism. He is also use these models to study the cellular and molecular mechanisms of hypolipidaemic and insulin-sensitizing drugs.

Regulation of hepatic and intestinal apolipoprotein B gene expression is also under intense investigation, particularly at the posttranscriptional levels of protein translocation and intracellular degradation.

Learn more: Adeli Lab

Research Description

Molecular and Cellular Biology of Lipoprotein Metabolism in Health and Disease

Khosorw Adeli’s basic research program is focused on the link between insulin resistant diabetes and dysregulation of lipoprotein metabolism. His group has been elucidating the molecular mechanisms linking diet-induced insulin resistance and metabolic dyslipidemia. His laboratory is employing animal models of insulin resistance to investigate the molecular mechanisms mediating the diabetogenic effect of fructose-rich diets, mechanisms of fructose-induced hepatic insulin resistance, and pathways leading to hepatic and intestinal lipogenesis and lipoprotein dysregulation.

Development of a Pediatric Reference Interval Database for Disease Biomarkers

Dr. Adeli has also been spearheading a national initiative CALIPER (Canadian Laboratory Initiative on Paediatric Reference Intervals) in collaboration with other pediatric health centres across Canada to establish a comprehensive database of pediatric reference intervals for laboratory biomarkers of pediatric disease.

CALIPER Reference Interval Database: Dr. Adeli has developed an online database for paediatric reference intervals . This database is continually updated as research produces new reference values for bio-markers of paediatric disease. The CALIPER database has been accepted worldwide as the most up to date pediatric reference resource available anywhere.

CALIPER Mobile App: This is the first mobile app developed by Dr. Adeli’s laboratory along with SickKids by the Research Institute’s IT team. The CALIPER App is a Smartphone app developed to provide pediatricians, family physicians, and other healthcare professionals with easy access to a reference database that will assist with result interpretation of medical tests done on children and adolescents. It provides ready access to a comprehensive and up to date pediatric reference interval database that allows accurate test result interpretation. The app provides reference intervals for over 60 tests routinely performed on children.
caliper

Awards & Distinctions

2014 — CSCC International Exchange Grant
2014 — Distinguished Service Award
2013 — NACB: Distinguished Abstracts Award
2012 — CSCC Award for Education Excellence
2012 — Outstanding Speaker Award
2011 — CSATVB Scientific Excellence Award
2011 — Oustanding Speaker Award

Courses Taught

BCH426H (BCH1426H) Regulation of Signalling Pathways
BCH2024H Lipid Metabolism in Health and Disease

Extra-Departmental Courses

MNU 111Y Metabolism and Nutrition
LMP1404H Molecular & Cellular Mechanisms of Disease
LMP1503H Signal Transduction Pathways in Normal and Diseased Tissues

Publications

View all publications on PubMed

GLP-1 and GLP-2 as yin and yang of intestinal lipoprotein production: evidence for predominance of GLP-2-stimulated postprandial lipemia in normal and insulin-resistant states
Hein GJ, Baker C, Hsieh J, Farr S, Adeli K
Diabetes. 2013 Feb;62(2):373-81  Read

Hepatic autophagy mediates ER stress-induced degradation of misfolded apolipoprotein B
Qiu W, Zhang J, Dekker MJ, Wang H, Huang J, Brumell JH, Adeli K
Hepatology. 2011 May;53(5):1515-25  Read

Complex Biological Pattern of Fertility Hormones in Children and Adolescents: A Study of Healthy Children from the CALIPER Cohort and Establishment of Pediatric Reference Intervals
Konforte D, Shea JL, Kyriakopoulou L, Colantonio D, Cohen AH, Shaw J, Bailey D, Chan MK, Armbruster D, Adeli K
Clin Chem. 2013 Aug;59(8):1215-27  Read

Marked Biological Variance in Endocrine and Biochemical Markers in Childhood: Establishment of Pediatric Reference Intervals Using Healthy Community Children from the CALIPER Cohort
Bailey D, Colantonio D, Kyriakopoulou L, Cohen AH, Chan MK, Armbruster D, Adeli K
Clin Chem. 2013 Sep;59(9):1393-405  Read

Closing the gaps in pediatric laboratory reference intervals: a CALIPER database of 40 biochemical markers in a healthy and multiethnic population of children
Colantonio DA, Kyriakopoulou L, Chan MK, Daly CH, Brinc D, Venner AA, Pasic MD, Armbruster D, Adeli K
Clin Chem 2012, 58(5):854-68  Read