Andrew Wilde

Andrew Wilde

Associate Professor

BSc, UCW Aberystwyth, 1990
PhD, University of Bristol, 1994
Postdoc, UC San Francisco, 1994-1998
Postdoc, Carnegie Institution of Washington, Dept Embryology, Baltimore, 1998-2001

Address MSB Room 4377
1 King's College Circle
Toronto, ON M5S 1A8
Lab Wilde Lab
Lab Phone 416 978 0782
Office Phone 416 946 7714
Email andrew.wilde@utoronto.ca

Andrew Wilde hails form the UK and moved to North America for Post-Doctoral work with Frances Brodsky at UCSF where he discovered novel links between receptor tyrosine kinase signaling and endocytosis. Subsequently, he moved to the Carnegie Institution in Baltimore to work with Yixian Zheng where he discovered a chromosome based signaling pathway that spatially organizes a mitotic cell. Andrew moved to Toronto in 2001 where he held a Canada Research Chair in Cell Biology. Andrew has continued his work examining how signals spatially co-ordinate mitosis with a particular focus on the co-ordination of chromosome segregation with membrane re-organization during cytokinesis and the role of tumor suppressors in regulating this process to ensure genome stability.

Research Lab

In the Wilde lab we study the molecular processes that drive cell division and the maintenance of genome stability. Using a combination of biochemical and imaging techniques, we exploit a variety of model systems, frogs, flies and tissue culture cells, to address different molecular questions related to cell division.

Learn more: Wilde Lab

Research Description

Cell Division in Tumor Formation and Oogenesis

Our research focus is to understand how cells divide. In particular we focus on the role of cell division in tumor formation and oogenesis. We take a multi-faceted approach combining biochemistry and live imaging to analyze cell division in frog eggs, Drosophila embryos and mammalian cells.

Publications

View all publications on PubMed

Anillin-dependent organization of septin filaments promotes intercellular bridge elongation and Chmp4B targeting to the abscission site
Matthew J. Renshaw, Jinghe Liu, Brigitte D. Lavoie and Andrew Wilde
Open Biol.. 2014 4:130190  Read

The BAR domain of Amphiphysin is required for pseudocleavage furrow tip (PFT)-tubule formation during cellularization in Drosophila embryos
Jing Su, Brenda Chow, Gabrielle L. Boulianne, and Andrew Wilde
Mol. Biol. Cell 2013 24: 1444-1453  Read

Cleavage furrow organization requires PIP2-mediated recruitment of anillin
Liu, J., Fairn, G.D., Ceccarelli, D.F., Sicheri, F. and Wilde A.
Curr. Biol. 2012 22:64-69  Read

The site of RanGTP generation can act as an organizational cue for mitotic microtubules.
Zonis J, Wilde A.
Biol Cell. 2011 103:421-34  Read

Anillin-mediated targeting of peanut to pseudocleavage furrows is regulated by the GTPase Ran.
Silverman-Gavrila RV, Hales KG, Wilde A.
Mol Biol Cell. 2008 19:3735-44  Read

Ran is required before metaphase for spindle assembly and chromosome alignment and after metaphase for chromosome segregation and spindle midbody organization.
Silverman-Gavrila RV, Wilde A.
Mol Biol Cell. 2006 17:2069-80  Read

Ran modulates spindle assembly by regulating a subset of TPX2 and Kid activities including Aurora A activation.
Trieselmann N, Armstrong S, Rauw J, Wilde A.
J Cell Sci. 2003 116:4791-8  Read

Ran localizes around the microtubule spindle in vivo during mitosis in Drosophila embryos.
Trieselmann N, Wilde A.
Curr Biol. 2002 12:1124-9  Read

Ran stimulates spindle assembly by changing microtubule dynamics and the balance of motor activities.
Wilde, A., Lizarraga, S.B., Zhang, L., Wiese, C., Gliksman, N.R., Walczak, C.E. and Zheng, Y.
Nature Cell Biology 2001 3:221-227  Read

Stimulation of microtubule aster formation and spindle assembly by the small GTPase Ran.
Wilde A. and Zheng Y.
Science 1999 284:1359-1362  Read