• Yeast_Brown Lab

Quantification of the yeast proteome

19 January 2018|0 Comments

The Brown lab, together with Anastasia Baryshnikova at Calico Labs, used computational analyses to normalize and convert 21 yeast protein abundance studies to the intuitive measurement of molecules per cell. They provide precise and accurate abundance measurements for greater than 90% of yeast proteins, making it the most comprehensive quantitation of the yeast proteome, and […]

  • ER and mRNA

Single molecule imaging of mRNAs by the Palazzo Lab provides new insight into Protein Synthesis in mammalian cells

3 January 2018|0 Comments

The Palazzo lab, in collaboration with Jeff Chao’s lab at the Friedrich Miescher Institute for Biomedical Research in Basel Switzerland, has resolved a long standing puzzle in how cells use mRNAs to synthesize proteins as detailed in a paper published in the most recent issue of Cell Reports (Single-Molecule Quantification of Translation-Dependent Association of mRNAs […]

  • rlk_nat_comm_image

How RNA decay promotes transcriptional rewiring during DNA replication stress

13 December 2017|0 Comments

Raphael Loll-Krippleber from the Brown lab describes how yeast cells exposed to DNA replication stress induced by the anti-cancer drug hydroxyurea use RNA decay to reprogram gene expression. Using complementary functional genomics approaches Raphael found that a specific mRNA encoding the transcriptional repressor Yox1 is degraded at P-bodies sites to prevent accumulation of the Yox1 […]

Cellular Signalling in Virtual Reality

4 December 2017|0 Comments

Aidin Balo in the Ernst laboratory delivers seminars about the structural details of rhodopsin signalling entirely in virtual reality for large audiences at international conferences using technology developed at Autodesk Life Sciences. A paper describing the novel aspects of the tool, the Autodesk Molecule Viewer, has been published in this month’s issue of Nature Methods (publicly accessible link: http://rdcu.be/z0HH)  A […]

Houry Lab uncovers over 1000 novel interactions of chaperones in yeast

4 December 2017|0 Comments

Kamran Rizzolo, in the laboratory of Professor Walid Houry, spoke with Faculty of Medicine’s writer Jim Oldfield about his lab’s recent  Cell Reports paper on the chaperone network in yeast.

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