• R.Melnyk

SickKids-led team discovers a drug that disarms a deadly hospital superbug

7 December 2018|0 Comments

In a new study that was published in Nature Communications, a team led by Roman Melnyk, Associate Professor in the Department of Biochemistry at the University of Toronto and Senior Scientist in the Molecular Medicine program at SickKids, screened thousands of small-molecule drugs to find any that might block the effects of the deadly toxins […]

  • Pfs4845-mAb-structure-team-figure

SickKids scientists and collaborators identify structure of key malaria protein with blocking antibody

21 November 2018|0 Comments

SickKids scientists have taken an important step forward on the path to finding effective biomedical interventions to halt the spread of malaria, a disease that affected an estimated 216 million people worldwide in 2016 alone.

Jean-Philippe Julien, Canada Research Chair in Structural Immunology, Assistant Professor in the Departments of Biochemistry and Immunology at the University of […]

A novel potential approach to treat cancer: Targetting NUAK2 to block oncogenic YAP/TAZ signaling during tumorigenesis

3 October 2018|0 Comments

 

Time-lapse imaging of Clover-YAP WT (first movie) and 5SA (second movie) in MDA-MB231 cells. Localization of Clover-YAP WT (wild type) and 5SA (mutant at all five LATS targeting sites) was monitored before and after addition of NUAK2 specific inhibitor, WZ4003. Note that the nuclear signal is gradually lost after addition of WZ4003 in cells expressing […]

  • Reithmeier research

Molecular Dynamics of a Blood Group Antigen

18 July 2018|0 Comments

In a collaborative project started during a sabbatical leave at Oxford, Reinhart Reithmeier and Antreas Kalli (Leeds) used computer simulations to characterize the dynamics of the human red blood cell anion transport protein Band 3 in a complex lipid bilayer.

The study was published on-line July 16th in PLOS Computational Biology.

The simulations showed that the signalling […]

  • Houry lab

Dysregulation of the human mitochondrial protease ClpP induces cancer cell death

4 July 2018|0 Comments

Acyldepsipeptides (ADEPs) compounds have bactericidal properties via dysregulating the activity of the highly conserved tetradecameric bacterial ClpP protease. In a recent publication in Cell Chemical Biology, Keith S. Wong and co-authors from the Houry group have reported on the identification of ADEP analogs that are potent dysregulators of the human mitochondrial ClpP (HsClpP). These analogs […]