• Organizers_2019

The inaugural Proteostasis Researchers in Canada (PRinCE) symposium

3 July 2019|0 Comments

The Proteostasis Researchers in Canada (PRinCE) inaugural meeting was held at the University of Toronto on June 10-11, 2019. The aim of this first symposium was to establish a network of researchers working in the field of protein homeostasis in Canada and to promote collaborations between labs working on topics relevant to proteostasis. These include […]

  • ClpP activated by ONC201

Structure of human mitochondrial ClpP protease – drug complex gains cover of Cancer Cell

24 May 2019|0 Comments

The crystal structure of ClpP protease activated by the experimental Phase 2 anti-cancer drug ONC 201, as determined by graduate student Ondrej Halgas in Emil F. Pai’s lab, was featured on the cover of the current issue (May 13th, 2019) of the journal Cancer Cell. Together with the laboratories of Walid Houry, Aaron Schimmer (Medical […]

The Ion Transporter NKCC1 Links Cell Volume to Cell Mass Regulation by Suppressing mTORC1

15 May 2019|0 Comments

Wael Demian from the Rotin lab at Sickkids, recently published a Cell Reports paper showing that the ion transporter NKCC1, known to regulate cell volume, forms a complex with the leucine transporter LAT1 and the Gln transporter ASCT2, and regulates mTORC1 activation via LAT1 and growth factors signaling. Thus, the work of Demian, et al. […]

  • David Andrews news post

Dr. David Andrews’ latest discovery highlighted

12 April 2019|0 Comments

By Matthew Pariselli

In a new eLife paper, Dr. David Andrews, a senior scientist at Sunnybrook Research Institute, and his lab show how an interaction between proteins promotes cancer cell survival.

Andrews, who is also a professor in the department of biochemistry at the University of Toronto, discovered that Bim, a pro-cell-death protein, binds to anti-cell-death proteins […]

  • Image_Brown lab

DNA Replication Stress Causes Mutations

4 March 2019|0 Comments

Grant Brown’s lab at the Donnelly Centre has characterized a new mutagenic ssDNA gap filling pathway in budding yeast. Their findings will be published in the March 7th issue of Molecular Cell.

DNA replication is a fundamental process that occurs before every cell division and must be completed in a timely and accurate fashion. Under normal […]