Avoiding catastrophe: Yeast study reveals clues to maintaining genome size

11 June 2018|0 Comments

By Jovana Drinjakovic

Study reveals an unexpected role for a well- known protein machinery in maintaining the correct DNA content with implications for cancer and other diseases

As cells divide, they must accurately split their DNA between the two daughter cells or risk having an uneven number of chromosomes which can lead to developmental disorders and cancer. […]

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New Tools for Biofilm Disruption

8 June 2018|0 Comments

Microbial biofilms grow on biotic and abiotic surfaces. The matrix of the biofilm that the pathogen produces protects them from the host immune response and antibiotics.  This proposes a major challenge for the treatment of chronic infections. In an article published in Plos Pathogens, Dustin J. Little and Roland Pfoh (Howell lab) and co-authors demonstrate […]

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Tipping Cell Signaling Pathways by Salts

11 April 2018|0 Comments

Mechanistic Insights into Allosteric Regulation of the A2A Adenosine G protein-Coupled Receptor by Physiological Cations

Libin Ye1,2, Chris Neale3, Adnan Sljoka4, Brent Lyda5, Dmitry Pichugin1,2, Nobuyuki Tsuchimura4, Sacha T. Larda1,2, Régis Pomès2,6, Angel E. García3, Oliver P. Ernst2,7, Roger K. Sunahara5, R. Scott Prosser1,2,*

In a recent paper appearing in Nature Communications, Libin Ye (Prosser lab) and […]

  • Ernst 2

Structure and Dynamics of Complexes of G Proteins and their Receptors

16 March 2018|0 Comments

Ned Van Eps in the Ernst laboratory used DEER spectroscopy together with molecular modeling techniques to map the structure of a complex between a G-protein-coupled receptor (GPCR) and its G protein. A paper describing the methodology used for characterizing the binding interface of the rhodopsin–G protein complex has recently been published in PNAS. The authors discovered that […]

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Quantification of the yeast proteome

19 January 2018|0 Comments

The Brown lab, together with Anastasia Baryshnikova at Calico Labs, used computational analyses to normalize and convert 21 yeast protein abundance studies to the intuitive measurement of molecules per cell. They provide precise and accurate abundance measurements for greater than 90% of yeast proteins, making it the most comprehensive quantitation of the yeast proteome, and […]