News & Events

Stagljar lab reveals new interactions among GPCRs

16 March 2017|

Using the modified membrane yeast two‐hybrid (MYTH) technology, researchers from the Stagljar lab mapped membrane protein interactions for clinically important G protein coupled receptors (GPCRs).

Read the full story on Faculty of Medicine website.

Read their paper on Molecular Systems Biology.

 

David Sabatini: “Regulation of Growth by the mTOR Pathway”

12 March 2017|

As part of the Connell Lecture Seminar Series, Dr. David Sabatini from MIT gave a seminar on how mTOR signalling, which controls cell growth, is regulated by the metabolic state of the cell.

Joseph Mougous: “Bacterial warfare in close quarters: molecular mechanisms underlying interbacterial antagonism”

1 March 2017|

As part of the Connell Lecture Seminar Series, Dr. Joseph Mougous from the University of Washington gave a seminar on bacterial transport systems that are used for bacterial warfare.

Dr. Sergio Grinstein wins the 2017 Canadian Science Publishing Senior Investigator Award!

1 March 2017|

Dr. Sergio Grinstein was selected by the Canadian Society for Molecular Biosciences as this year’s recipient of the  Canadian Science Publishing Senior Investigator Award. He will present his award talk at the upcoming meeting of the CSMB in Ottawa in May of this year.

Susan Buchanan: “Structural insight into the biogenesis of beta barrel membrane proteins”

22 February 2017|

As part of the Connell Lecture Seminar Series, Dr. Susan Buchanan from the NIH gave a seminar on bacterial transporter proteins.

Researchers revisit the role of conformational dynamics and the protein ensemble in catalysis

21 February 2017|

Houry lab identifies a novel regulator of respiratory chain complexes

13 February 2017|

Graphical abstract_120616

An interaction between the respiratory enzyme fumarate reductase (Frd, also known as Complex II) and an ATPase has been identified in E. coli by the Houry lab. The research shows that the RavA ATPase, belonging to a poorly characterized but ubiquitous MoxR family of AAA+ ATPases, associates with the Frd respiratory enzyme through an adaptor, which the group named ViaA. […]

Ernst Lab discover new way to crystallize membrane proteins

7 February 2017|

The laboratory of Dr. Oliver Ernst has used X-ray crystallography to determine the structure of a membrane protein that never left a lipid-bilayer environment (i.e., without the use of conventional detergents). The work, published in Structure and highlighted on the Journal’s cover, was led by postdoctoral fellow Dr. Jana Broecker. Polymer-bounded lipid nanodiscs were used to extract and purify membrane proteins with their surrounding lipids and allowed […]

Ensminger lab discovers a class of bacterial effectors with novel regulatory activities

3 February 2017|

Many bacterial pathogens modulate their hosts through complex arsenals of effector proteins that are injected into host cell during infection. Indeed, the concept that effectors target host proteins and processes to modulate their activities is central to the current molecular understanding of host-pathogen interactions. Legionella pneumophila, the causative agent of a deadly pneumonia known as Legionnaires’ disease, has over 300 effectors, which is the largest known arsenal amongst bacterial pathogens. […]

Lingwood Lab discover new approach to rescue endogenous misfolded proteins

1 February 2017|

Newly made proteins which do not quite achieve the correct 3D shape in the ER are moved to the cell cytoplasm via a specific membrane pore, and broken down. Many disease causing gene mutations e.g. in cystic fibrosis, also result in misfolding of the mutant protein, and its transport though this pore, for cytoplasmic degradation. This pore is hijacked by some bacterial toxins which need to access the cytoplasm to […]

An artistic interpretation of the enzyme fluoroacetate dehalogenase binding substrate (green) in the left subunit and releasing bound water molecules (red) in the right-hand subunit.

The roles of protein dynamics and water networks in catalysis visualized

1 February 2017|

The dimeric enzyme fluoroacetate dehalogenase is one of only a handful of protein catalysts that can break the strongest bond in organic chemistry, the one between carbon and fluorine atoms, in the process transforming the highly toxic pesticide fluoroacetate into glycolate, a benign molecule.  The laboratories of Emil Pai and Scott Prosser, together with the group of Régis Pomès and collaborators in the US and Japan, have […]

Stagljar lab map interactions between receptor tyrosine kinases (RTKs) and protein tyrosine phosphatases (PTPs)

1 February 2017|

Featured on the front page of Molecular Cell, the research led by Dr. Igor Stagljar captured and mapped interactions between receptor tyrosine kinases (RTKs) and protein tyrosine phosphatases (PTPs) in human cells, leading to new and improved cancer therapies.

Read the full story on the Faculty of Medicine and The Varsity websites.