News & Events

2017-2018 Cohort of 2nd year Biochemistry Specialists

1 December 2017|

The first half of the academic school year is almost over and the Department of Biochemistry is pleased to welcome our incoming class of 2nd year Biochemistry Specialists.  The Biochemistry Specialist program is open to a small group of high caliber students who wish to gain an in depth understanding of the molecular mechanisms at play and practice essential critical thinking […]

Dr. Reinhart Reithmeier – featured in UofT podcast, Raw Talk

6 November 2017|

Dr. Reinhart Reithmeier talks on “student engagement” on the U of T podcast Raw Talk: http://www.rawtalkpodcast.com/2017/03/10/episode-11-dr-reinhart-reithmeier/

 

 

Andy Martin “Substrate processing and mechanochemical coupling of the 26S proteasome – a fine-tuned molecular machine”

25 October 2017|

As part of the Connell Lecture Seminar Series, Prof. And Martin from UC Berkeley gave a seminar on how proteasomes recognize and degrade ubiquitinated proteins.

Bob Varelas, “Polarity regulated Hippo Pathway signaling in lung development and disease”

4 October 2017|

As part of the Connell Lecture Seminar Series, Bob Varelas from Boston University spoke to us on how the Hippo Pathway regulates various aspects of lung development.

Mapping the molecular chaperone network

4 October 2017|

Rizzolo et al. from the Houry group provided a comprehensive view of molecular chaperone function in the cell through the use of a systematic global integrative network approach based on physical (protein-protein) and genetic (gene-gene or epistatic) interaction mapping. The analysis revealed the presence of a large chaperone functional supercomplex, which was named the NAJ chaperone complex, encompassing Hsp40, Hsp70, Hsp90, CCT and small Hsps. Many chaperones were found […]

SickKids scientists obtain blueprint of molecular target for blood cancer and autoimmune therapies

4 October 2017|

Researchers at The Hospital for Sick Children (SickKids) have been exploring the molecular structure of immune cell components, and how gaining an understanding of their anatomical organization can help develop future targeted therapies for blood cancers and autoimmune diseases. Dr. Jean-Philippe Julien and co-authors, Dr. June Ereño-Orbea and Taylor Sicard provide the details of their study, “Molecular basis of human CD22 function and therapeutic targeting”, published October 2 in […]

Wolfgang Baumeister, “The Molecular Machinery of Protein Degradation – Structural Studies ex situ and in situ”

20 September 2017|

As part of the Connell Lecture Seminar Series, Prof. Wolfgang Baumeister from the Max Planck Institute of Biochemistry gave a seminar on a cryo-EM based investigation of proteasomes in cells.

The second annual Biochemistry Departmental Retreat at the Kempenfelt Centre

31 August 2017|

The second annual Biochemistry Departmental Retreat was held at the Kempenfelt Centre on August 30-31st, 2017. The retreat not only allowed the Department to celebrate our newest scientific discoveries, but also to allow everyone to see old friend and meet new colleagues. It also allowed incoming graduate rotation students to sample all of the exciting science that is happening throughout the Department. This year, the retreat focused on grad students […]

How GPCRs use phosphorylation codes for arrestin recruitment

23 August 2017|

DEER spectroscopy by Ned van Eps in the Ernst lab was used to validate the crystal structure of the phosphorylated G-protein-coupled receptor (GPCR) rhodopsin in complex with arrestin. EPR measurements confirmed the location of the C-terminal tail of rhodopsin on a arrestin binding surface in a non-crystallographic environment. GPCRs are among the most important cell surface receptors controlling nearly all of our physiology. Termination of G-protein-mediated signalling by an […]

Dr. Clifford Lingwood – speaking at Discovery on Target

4 August 2017|

Dr. Clifford Lingwood will be talking at the Discovery on Target – Tackling Rare Diseases conference  in September 2017. Read more about it here.

Bear Lab shows that a new Cystic Fibrosis treatment improves function from a rare CFTR mutation in patient tissue

14 July 2017|

The laboratory of Christine Bear, together with the group of Régis Pomès and collaborators at The Hospital for Sick Children and Proteostasis Therapeutics, used in silico, in vitro and ex vivo techniques to comprehensively understand the consequences of a rare Cystic Fibrosis (CF) disease-causing mutation in the CFTR gene: c.3700 A>G (ΔI1234_R1239), and subsequently develop a novel mechanism-based therapeutic strategy.

Steven Molinski, first author of the study and recent […]

Announcing our 4th Annual Postdoc and Senior PhD Professional Development Workshop

26 June 2017|

“Strategic Self-Marketing: Landing the Job”

Dates: Fridays, July 14 and July 28, 2017.

Time: 10 am – 4 pm

Location: Medical Sciences Building Room 5231

Previous attendees are now at biotech, pharma, international postdoc fellowships, start-ups, knowledge translation, communications.

Attendees are expected to work a few hours outside of class to prepare career action plans, resumes, cover letters and presentations. Agenda will cover highlights in Dr. Lee’s GPD class. http://biochemistry.utoronto.ca/courses/bch2024h-professional-development/

Please register by noon […]