News & Events

Mechanism of misfolded protein rescue.

Lingwood Lab discover new approach to rescue endogenous misfolded proteins

1 February 2017|

Newly made proteins which do not quite achieve the correct 3D shape in the ER are moved to the cell cytoplasm via a specific membrane pore, and broken down. Many disease causing gene mutations e.g. in cystic fibrosis, also result in misfolding of the mutant protein, and its transport though this pore, for cytoplasmic degradation. This pore is hijacked by some bacterial toxins which need to access the cytoplasm to […]

An artistic interpretation of the enzyme fluoroacetate dehalogenase binding substrate (green) in the left subunit and releasing bound water molecules (red) in the right-hand subunit.

The roles of protein dynamics and water networks in catalysis visualized

1 February 2017|

The dimeric enzyme fluoroacetate dehalogenase is one of only a handful of protein catalysts that can break the strongest bond in organic chemistry, the one between carbon and fluorine atoms, in the process transforming the highly toxic pesticide fluoroacetate into glycolate, a benign molecule.  The laboratories of Emil Pai and Scott Prosser, together with the group of Régis Pomès and collaborators in the US and Japan, have […]

Molecular Cell 2

Stagljar lab map interactions between receptor tyrosine kinases (RTKs) and protein tyrosine phosphatases (PTPs)

1 February 2017|

Featured on the front page of Molecular Cell, the research led by Dr. Igor Stagljar captured and mapped interactions between receptor tyrosine kinases (RTKs) and protein tyrosine phosphatases (PTPs) in human cells, leading to new and improved cancer therapies.

Read the full story on the Faculty of Medicine and The Varsity websites.

Davidson and Maxwell help discover off-switches for CRISPR

31 January 2017|

 

Featured on the cover of Cell, Biochemistry’s Dr. Alan Davidson and Dr. Karen Maxwell helped to discover how to turn off CRISPR. Read the full story.

An image of GPD logo.

Biochemistry GPD featured by NSF

10 January 2017|

Our GPD program has been highlighted as one of four North American STEM professional development programs by Council of Graduate Schools/National Science Foundation in their just published report. Check out page 27!

CGS/NSF report on STEM professional development

A photo of Dr. Charles Deber.

Charles Deber wins the 2017 Merrifield Award of the American Peptide Society

10 January 2017|

Dr. Charles Deber, Senior Scientist in the Program in Molecular Structure & Function, Research Institute, Hospital for Sick Children, and Professor in the Department of Biochemistry, University of Toronto, has received the 2017 Bruce Merrifield Award of the American Peptide Society. The Award was created in 1997 in honour of Dr. R. Bruce Merrifield, who won the Nobel Prize in Chemistry in 1984. The Award is presented every two years […]

A phote of Professor Penney Gilbert with the Honorable Kirsty Duncan Minister of Science

Gilbert named Canada Research Chair in Endogenous Repair

2 December 2016|

Biochemistry faculty member Penney Gilbert was named a Tier II Canada Research Chair in Endogenous Repair for her work on understanding the mechanisms that control muscle stem cell fate during skeletal muscle homeostasis and regeneration.

Read the full story:

http://www.ibbme.utoronto.ca/news/penney-gilbert-named-canada-research-chair/

http://news.engineering.utoronto.ca/two-u-t-engineering-researchers-awarded-canada-research-chairs/

https://www.utoronto.ca/news/25-top-u-t-scholars-named-canada-research-chairs

 

Atomic model for the membrane-embedded motor of a eukaryotic V-ATPase

Proton pumping region of rotary ATPases revealed

3 November 2016|

In work led by postdoctoral fellow Mohammad T. Mazhab-Jafari, the Rubinstein laboratory used electron cryomicroscopy (cryo-EM) to determine the atomic structure of the membrane-bound region of a eukaryotic V-ATPase. This study, which was published in Nature, gives the first high-resolution structure for the membrane region of any rotary ATPase, a family of enzymes that includes proton pumping V-ATPases and proton-driven ATP synthases. The structure reveals several surprising features of […]

2ndyearbchspecialists-2016-320x240

Welcome 2nd year Biochemistry Specialists!

28 October 2016|

The academic school year is off to a great start and the Department of Biochemistry is pleased to welcome our incoming class of Biochemistry Specialists.  The Biochemistry Specialist program is open to a small group of high caliber students who wish to pursue a career in research. This year’s cohort, see here in with Dr. Sian Patterson, 2nd from the left, has begun their laboratory training in BCH242Y, […]

Justin Nodwell, Chair
Department of Biochemistry

Doctors’ Notes: Changing the way we fight bacteria

24 October 2016|

Featured in this week’s Doctors’ Notes column in Toronto Star, Prof. Justin Nodwell re-examines antimicrobial resistance and discusses what our researchers are doing to fight bacteria.

Read the full article here.

A photo of Natalie Bamford.

Bamford awarded a 2016 Vanier Canada Graduate Scholarship

3 October 2016|

Natalie Bamford, a former University of Toronto Biochemistry Specialist and current PhD student in the Howell lab, was recently awarded a prestigious Vanier Canada Graduate Scholarship from the Natural Sciences and Engineering Research Council of Canada (NSERC) to continue her studies. Natalie’s research focuses on understanding the biosynthesis of the fungal biofilm exopolysaccharide galactosaminogalactan.

“This is a new exciting project as little is known of fungal exopolysaccharide biosynthesis. I […]

A photo of Trillium group.

GPD hosts Site Visit to Trillium Therapeutics

3 October 2016|

Nine PhD trainees and early PDFs attended Trillium Therapeutics on September 30, 2016 to meet with their President and CEO, Dr. Niclas Stiernholm and their research team. We learned all about their R & D, their innovative industry postdoctoral program, biotech culture and enjoyed some company chocolates. Thank-you to Trillium!