How bacterial invaders are sensed in the gut
A new paper in the latest issue of Science describes how the bacterial-sensing proteins, NOD1/2, are recruited to the membranes of our gut cells for them to function to initiate a proper immune response. This involves the addition of a lipid, palmitoyl, to NOD1/2 by the palmitoyl-transferase ZDHHC5. Importantly variants of NOD2 that are associated […]
Angus McQuibban awarded major funding for anti-neurodegenerative diseases drug discovery by AI
Professor G. Angus McQuibban has just been awarded a $2.3-million Genome Canada grant.
The GAPP grant in a partnership with Cyclica and Rosetta Therapeutics (founded by Professors Angus McQuibban and Peter Lewis) will support drug discovery related to treating people with the long-term neurodegenerative diseases and will involve the use of artificial intelligence and machine learning. (full story […]
Red Cell Anion Exchanger Makes the Cover of Biophysical Journal
Dario De Vecchis, a post-doctoral fellow in the laboratory of Dr. Antreas Kalli at Leeds, University, in a collaborative project with Reinhart Reithmeier used molecular dynamics simulations to build the first atomic scale model of the red cell anion exchanger in a complex lipid bilayer that mimics the native membrane. This work appeared in the […]
Pai lab visualize the inner workings of an enzyme
Researchers from the Emil Pai Lab in collaboration with the Miller Lab (Depts. of Chemistry and Physics, University of Toronto) have pieced together a time-lapse movie revealing all the major steps during the catalytic cycle of an enzyme. This study, published in Science, is the most detailed depiction of such a process to date.
The communication […]
2019 Biochemistry Golf Day
The forecasted rain stayed away for our 2019 Golf Day and golfers enjoyed a beautiful cloudy day with the sun making an appearance near the end of the round. Twenty-eight students, admins, Faculty and more than a few ringers headed out to the Flemingdon Park 9-hole Golf Course in mid-town Toronto. Each team had its […]