The latest study from the Moraes lab characterized a novel heme uptake pathway in A. baumannii, which is listed by the WHO and CDC as one of the top priority pathogens for research and development of new therapeutics. In response to being in iron restricted environments such as a human host during infection, A. baumannii produces a heme binding protein (HphA) secreted by an outer membrane protein called Slam. This […]
Click here to read the full edition: Email newsletter – November 2021
“Jocelyn Nurtanto, from Professor Liliana Attisano’s lab, won the Best e-Poster Pitch Prize for presenting of a method she helped develop that allows culturing three-dimensional human lung organoids for a deeper study of lung development and disease and for drug discovery.”
To read more, click here: Virtual Symposium Gives Summer Students Platform to Present […]
Mitochondria are essential organelles regulating a myriad of cellular processes ranging from cell death to various signaling pathways. Vital to mitochondrial functions is their ability to modulate their shape via two opposing processes: fusion and fission. Fission, characterized by the division of one mitochondrion in two daughter mitochondria, is a complex process involving the participation of multiple organelles such as the endoplasmic reticulum (ER) and lysosomes. In this manuscript, research […]
Click here to read the full edition: Email newsletter – Sept 2021
Click here to read the complete edition: Email newsletter – August 2021
Bacterial specialized metabolites may more commonly be produced and act in combination than previously appreciated. In a new review for Nature Microbiology, postdoctoral fellow Kirsten Meyer and Professor Justin Nodwell discuss the biology and applications of combination metabolites with synergistic antimicrobial activity. Bacteria from diverse phyla and environments produce synergistic metabolite combinations. Despite this diversity, there are conserved genetic and biosynthetic strategies for production of the combinations. The metabolite combinations […]
Professor Alex Palazzo is co-organizing with Jomon Joseph (National Centre For Cell Science, Pune) a Workshop on RanBP2/Nup358 and Acute Necrotizing Encephalopathy, November 10th to 12th (9AM to 12:30PM, EST). The workshop is free and will be held over Zoom. If you would like to attend, please register (see the link below). If you, or your trainees, would like to present your work, we have reserved slots for […]
Inclusion begins with encouraging and providing opportunities for everyone to get involved. On Wednesday, March 24, 2021, the Department of Biochemistry’s Wellness, Inclusion, Diversity and Equity (WIDE) committee, held our department’s very first Biochemistry Day. The half-day event was designed in partnership with the University of Toronto, St. George Outreach Site of Let’s Talk Science (LTS), which is a Canadian charitable organization dedicated to promoting youth interest in science, tech, […]
Nuclear reorganization, including the localization of proteins into discrete subnuclear foci, is a hallmark of the cellular response to DNA damage and replication stress. These foci are thought to represent transient environments or repair factories, in which the lesion is sequestered with molecules and co-factors that catalyze repair. For example, nuclear foci contain signaling proteins that recruit transducer proteins. One important class of transducers is the structure-selective endonucleases, such as […]
Professor Stephane Angers has been appointed director of the Donnelly Centre for Cellular and Biomolecular Research for a five-year term beginning September 1, 2021.
Angers, who is currently Associate Dean of Research in the Leslie Dan Faculty of Pharmacy, holds appointments with the Leslie Dan Faculty of Pharmacy and the Department of Biochemistry at the Temerty Faculty of Medicine. He is also the founding co-director of the […]
