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David
H. MacLennan
Professor
B.Sc. Agriculture, University of Manitoba,
l959
M.Sc., Purdue University, 1961
Ph.D., Purdue University, 1963
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Banting & Best
Department of Medical Research, Room 305A
416-978-6408
david.maclennan@utoronto.ca
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Membrane Transport and
Molecular Biology of Membrane Proteins
Go to Lab
Homepage
Research Synopsis
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From
Structure/Function Relationships in the Calcium ATPase
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The overall
objectives of research in our laboratory are to understand
how normal sarcoplasmic reticulum proteins carry out their
functions of calcium transport, sequestration and release
and how mutant forms cause abnormalities or disease. In
order to accomplish these objectives, we have isolated
many of the sarcoplasmic reticulum proteins and characterized
them. We have also utilized recombinant DNA technology
to advance our knowledge of the primary structures of
these proteins, of their mechanisms of action, and of
the roles that mutant proteins play in human genetic disease.
The specific areas of research focus are:
- Structure/Function relationships in the Calcium
ATPase
- Interactions of SERCA molecules with phospholamban
and sarcolipin
- SERCA1 and sarcolipin in Brody disease
- Sarcoplasmic reticulum proteins in cardiomyopathy
- Calcium release channel (ryanodine receptors)
- Malignant Hyperthermia and Central Core Disease
- Calcium binding proteins
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Selected Publications
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Publications are listed on the MacLennan lab homepage.
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