Peter N. Lewis Professor

University of Calgary, 1968
Cornell University, 1972
Portsmouth Polytechnic, 1972-74
Visiting Scientist, University of California at
Davis, 1985
Department of Biochemistry, 1991-01
NCBI, 1997
Program in Proteomics and Bioinformatics, 1998
Visiting Professor,
National University of Singapore, 2002
Visiting Scientist,
Institute for Systems Biology, 2002

Vice Dean, Research and International Relations, Faculty of Medicine 2002 - 2009

Associate Vice President, Research, Simcoe Hall 2010 -

Office: Medical Sciences Building, Room 5318

last update 10/08/10

Research Interests




Histone Deacetylases



Nucleosome Assembly Proteins



Histone Acetyltransferases



Protein Foldiung




Selected Publications

Association with the Origin Recognition Complex suggests a novel role for histone acetyltransferase Hat1p/Hat2p. Suter B, Pogoutse O, Guo X, Krogan NJ, Lewis P, Greenblatt JF, Rine J, Emili A. BMC Biol. 2007 Sep 19;5(1):38

Use of substrate analogs and mutagenesis to study substrate binding and catalysis in the SIR2 family of NAD-dependent protein deacetylases. Khan, A. Lewis, P.N. J Biol Chem. 2006 Apr 28;281:11702-1

Unstructured conformations are a substrate requirement for the Sir2 family of NAD-dependent protein deacetylases. Khan, A. Lewis, P.N. (2005) J Biol Chem.;280(43):36073-8

Epstein-Barr nuclear antigen 1 binds and destabilizes nucleosomes at the viral origin of latent DNA replication. Avolio-Hunter, T.M., Lewis, P.N. and Frappier, L. (2001) Nucleic Acids Res.29, 3520-3528.

Assembly, remodeling, and histone binding capabilities of yeast nucleosome assembly protein 1. McQuibban, A., Cappelli, C. and Lewis, P. N. (1998) J. Biol. Chem. 273, 6582-6590 (1998)

Histone-induced damage of a mammalian epithelium: the role of protein and membrane structure. Kleine T.J., Lewis P.N., Lewis S.A. (1997) Am J Physiol 273, C1925-C1936

Histone-induced damage of a mammalian epithelium: the conductive effect. Kleine T.J., Gladfelter A., Lewis P.N.and Lewis S.A. (1995) Am J Physiol May;268(5 Pt 1):C1114-C1125



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