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Peter
N. Lewis
Professor
B.SC., University
of
Calgary,
1968
Ph.D., Cornell
University,
1972
PDF Portsmouth
Polytechnic,
1972-74
Visiting Scientist, University of
California at Davis,
1985
Chair, Department
of
Biochemistry,
1991-01
Scientist, NCBI,
1997
Director, Program
in Proteomics and
Bioinformatics,
1998
Visiting Professor, National
University of
Singapore,
2002
Visiting Scientist, Institute
for Systems
Biology,
2002
Vice Dean,
Research and International Relations, Faculty
of
Medicine
2002 - 2009
Associate Vice President,
Research, Simcoe Hall
2010 -
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Office: Medical Sciences Building, Room 5318
416-978-6759
peter.lewis@utoronto.ca
last update 10/08/10
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Research Interests
Prions
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TBA
Histone Deacetylases
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TBA
Nucleosome Assembly Proteins
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TBA
Histone Acetyltransferases
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TBA
Protein Foldiung
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TBA
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Selected
Publications
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Association with the Origin Recognition Complex suggests a novel role for histone acetyltransferase Hat1p/Hat2p. Suter B, Pogoutse O, Guo X, Krogan NJ, Lewis P, Greenblatt JF, Rine J, Emili A. BMC Biol. 2007 Sep 19;5(1):38
Use of substrate analogs and mutagenesis to study substrate binding and catalysis in the SIR2 family of NAD-dependent protein deacetylases. Khan, A. Lewis, P.N. J Biol Chem. 2006 Apr 28;281:11702-1
Unstructured
conformations are a substrate requirement for the
Sir2 family of NAD-dependent protein
deacetylases.
Khan, A. Lewis, P.N. (2005) J Biol
Chem.;280(43):36073-8
Epstein-Barr
nuclear antigen 1 binds and destabilizes
nucleosomes at the viral origin of latent DNA
replication.
Avolio-Hunter, T.M., Lewis, P.N. and Frappier, L.
(2001) Nucleic Acids Res.29, 3520-3528.
Assembly,
remodeling, and histone binding capabilities of
yeast nucleosome assembly protein
1.
McQuibban, A., Cappelli, C. and Lewis, P. N. (1998)
J. Biol. Chem. 273, 6582-6590 (1998)
Histone-induced
damage of a mammalian epithelium: the role of
protein and membrane
structure.
Kleine T.J., Lewis P.N., Lewis S.A. (1997) Am J
Physiol 273, C1925-C1936
Histone-induced
damage of a mammalian epithelium: the conductive
effect.
Kleine T.J., Gladfelter A., Lewis P.N.and Lewis
S.A. (1995) Am J Physiol May;268(5 Pt
1):C1114-C1125
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