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C.
James Ingles
Professor
BSc. University of Toronto
PhD. University of British Columbia |
Banting
& Best Department of Medical Research, Rooms 103/107
416-978-7400
cj.ingles@utoronto.ca |
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Molecular Mechanisms Regulating
Transcription of RNA in Eukaryotic Cells
Research Synopsis
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My laboratory
investigates both RNA transcription and DNA repair.
We are interested in the function of the tandemly repeated
heptapeptide domain of eukaryotic RNA polymerase II, its
CTD, which was discovered in my laboratory. We have identified
several CTD-binding proteins that may couple ongoing transcription
and pre-mRNA processing events.
We are also investigating DNA repair mechanisms in human
and yeast cells. DNA repair is of interest as cancer susceptibility
results from inherited mutations in DNA repair genes.
We are currently studying interactions between replication
protein A and other DNA repair proteins including the
human BRCA1 and BRCA2 proteins. Mutations in BRCA genes
account for most cases of familial breast cancer, likely
by impairing double-strand break repair.
Work on my laboratory is funded by a CIHR grant.
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Selected Publications
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| Recent publications in molecular
biology: PubMed |
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